BRD-K01896723_2-morpholino-N-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

283 genes differentially expressed following the BRD-K01896723_2-morpholino-N-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACPP acid phosphatase, prostate
ADD3 adducin 3 (gamma)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CAPN2 calpain 2, (m/II) large subunit
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CD9 CD9 molecule
CD93 CD93 molecule
CFB complement factor B
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
COLEC12 collectin sub-family member 12
CTGF connective tissue growth factor
CTSB cathepsin B
CXADR coxsackie virus and adenovirus receptor
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
ECM1 extracellular matrix protein 1
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
ESR2 estrogen receptor 2 (ER beta)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FHOD3 formin homology 2 domain containing 3
FST follistatin
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HLA-B major histocompatibility complex, class I, B
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
KIAA1462 KIAA1462
LEF1 lymphoid enhancer-binding factor 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MDFIC MyoD family inhibitor domain containing
MEIS2 Meis homeobox 2
MMP9 matrix metallopeptidase 9
MN1 meningioma (disrupted in balanced translocation) 1
MSN moesin
MX1 MX dynamin-like GTPase 1
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NREP neuronal regeneration related protein
NRGN neurogranin (protein kinase C substrate, RC3)
OLFM4 olfactomedin 4
ORM1 orosomucoid 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCP4 Purkinje cell protein 4
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFC platelet derived growth factor C
PDIA3 protein disulfide isomerase family A, member 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PLVAP plasmalemma vesicle associated protein
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
S100A9 S100 calcium binding protein A9
SDC2 syndecan 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SMC1A structural maintenance of chromosomes 1A
SOCS2 suppressor of cytokine signaling 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STC1 stanniocalcin 1
SULF1 sulfatase 1
TKTL1 transketolase-like 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPP1 tripeptidyl peptidase I
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZDHHC11 zinc finger, DHHC-type containing 11
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ADNP activity-dependent neuroprotector homeobox
AGR2 anterior gradient 2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMCX6 armadillo repeat containing, X-linked 6
ARMT1 acidic residue methyltransferase 1
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BCAS3 breast carcinoma amplified sequence 3
BTBD3 BTB (POZ) domain containing 3
C1ORF174 chromosome 1 open reading frame 174
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNF cyclin F
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CHERP calcium homeostasis endoplasmic reticulum protein
CHPT1 choline phosphotransferase 1
COIL coilin
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EED embryonic ectoderm development
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF4B eukaryotic translation initiation factor 4B
EIF4E eukaryotic translation initiation factor 4E
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB2 erb-b2 receptor tyrosine kinase 2
EXOSC4 exosome component 4
FA2H fatty acid 2-hydroxylase
FABP7 fatty acid binding protein 7, brain
FAM35A family with sequence similarity 35, member A
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GDI2 GDP dissociation inhibitor 2
GLOD4 glyoxalase domain containing 4
GRWD1 glutamate-rich WD repeat containing 1
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
HSPA4L heat shock 70kDa protein 4-like
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
IST1 increased sodium tolerance 1 homolog (yeast)
JMJD6 jumonji domain containing 6
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT7 keratin 7, type II
KYNU kynureninase
LTF lactotransferrin
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MED13 mediator complex subunit 13
MED6 mediator complex subunit 6
MLPH melanophilin
MREG melanoregulin
MRFAP1L1 Morf4 family associated protein 1-like 1
MRPS30 mitochondrial ribosomal protein S30
MTMR4 myotubularin related protein 4
MYBPC1 myosin binding protein C, slow type
NCOA3 nuclear receptor coactivator 3
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NGDN neuroguidin, EIF4E binding protein
NNMT nicotinamide N-methyltransferase
NOL11 nucleolar protein 11
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
OPN3 opsin 3
OXA1L oxidase (cytochrome c) assembly 1-like
OXTR oxytocin receptor
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCNA proliferating cell nuclear antigen
PDS5B PDS5 cohesin associated factor B
PHF20 PHD finger protein 20
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PROM1 prominin 1
PRPF4 pre-mRNA processing factor 4
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PTRH2 peptidyl-tRNA hydrolase 2
PUF60 poly-U binding splicing factor 60KDa
RAD9A RAD9 homolog A (S. pombe)
RAE1 ribonucleic acid export 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM14 RNA binding motif protein 14
RBM15 RNA binding motif protein 15
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RNMT RNA (guanine-7-) methyltransferase
RNPS1 RNA binding protein S1, serine-rich domain
RPL36AL ribosomal protein L36a-like
RPP25 ribonuclease P/MRP 25kDa subunit
RPS11 ribosomal protein S11
SCAF8 SR-related CTD-associated factor 8
SETD5 SET domain containing 5
SFPQ splicing factor proline/glutamine-rich
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMG8 SMG8 nonsense mediated mRNA decay factor
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPDEF SAM pointed domain containing ETS transcription factor
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBP TATA box binding protein
TBX2 T-box 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAM transcription factor A, mitochondrial
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMPO thymopoietin
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TUBD1 tubulin, delta 1
TXLNA taxilin alpha
TXNDC9 thioredoxin domain containing 9
UBE2S ubiquitin-conjugating enzyme E2S
UBL3 ubiquitin-like 3
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
ZDHHC7 zinc finger, DHHC-type containing 7
ZMYM2 zinc finger, MYM-type 2
ZNF330 zinc finger protein 330