BRD-K01896723_2-morpholino-N-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

220 genes differentially expressed following the BRD-K01896723_2-morpholino-N-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AEBP1 AE binding protein 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ASPN asporin
ATF3 activating transcription factor 3
BSG basigin (Ok blood group)
C21ORF33 chromosome 21 open reading frame 33
CD177 CD177 molecule
CETN2 centrin, EF-hand protein, 2
CLIC5 chloride intracellular channel 5
COL10A1 collagen, type X, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A1 collagen, type VI, alpha 1
CTSZ cathepsin Z
DCN decorin
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
EFHD1 EF-hand domain family, member D1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
FGFR3 fibroblast growth factor receptor 3
FLOT1 flotillin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GPM6A glycoprotein M6A
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
KIAA0226L KIAA0226-like
LEF1 lymphoid enhancer-binding factor 1
LTA4H leukotriene A4 hydrolase
LUM lumican
MAGT1 magnesium transporter 1
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MME membrane metallo-endopeptidase
MMP11 matrix metallopeptidase 11
MMP9 matrix metallopeptidase 9
MT1F metallothionein 1F
MT1M metallothionein 1M
MXRA5 matrix-remodelling associated 5
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NREP neuronal regeneration related protein
PADI2 peptidyl arginine deiminase, type II
PFKM phosphofructokinase, muscle
PLAT plasminogen activator, tissue
PODXL podocalyxin-like
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROSC proline synthetase co-transcribed homolog (bacterial)
PSPH phosphoserine phosphatase
RGS10 regulator of G-protein signaling 10
RPRD1A regulation of nuclear pre-mRNA domain containing 1A
SCARB2 scavenger receptor class B, member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
TNNT1 troponin T type 1 (skeletal, slow)
TPD52 tumor protein D52
TUBA1A tubulin, alpha 1a
VIM vimentin
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BMP4 bone morphogenetic protein 4
BRIX1 BRX1, biogenesis of ribosomes
C10ORF2 chromosome 10 open reading frame 2
C14ORF169 chromosome 14 open reading frame 169
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNF cyclin F
CD3EAP CD3e molecule, epsilon associated protein
CDC123 cell division cycle 123
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHERP calcium homeostasis endoplasmic reticulum protein
CSNK1D casein kinase 1, delta
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP6 dual specificity phosphatase 6
F5 coagulation factor V (proaccelerin, labile factor)
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
FZD7 frizzled class receptor 7
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA2 GATA binding protein 2
GEM GTP binding protein overexpressed in skeletal muscle
GEMIN4 gem (nuclear organelle) associated protein 4
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
GTPBP4 GTP binding protein 4
H2AFX H2A histone family, member X
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
INPP1 inositol polyphosphate-1-phosphatase
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
JUND jun D proto-oncogene
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KIN Kin17 DNA and RNA binding protein
KLHL21 kelch-like family member 21
KLK10 kallikrein-related peptidase 10
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LGALS1 lectin, galactoside-binding, soluble, 1
MCL1 myeloid cell leukemia 1
MCM10 minichromosome maintenance complex component 10
MED17 mediator complex subunit 17
METTL18 methyltransferase like 18
MFSD5 major facilitator superfamily domain containing 5
MTPAP mitochondrial poly(A) polymerase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NOL11 nucleolar protein 11
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NOSIP nitric oxide synthase interacting protein
NQO1 NAD(P)H dehydrogenase, quinone 1
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PARP2 poly (ADP-ribose) polymerase 2
PDE4B phosphodiesterase 4B, cAMP-specific
PELO pelota homolog (Drosophila)
PFKP phosphofructokinase, platelet
PLAGL2 pleiomorphic adenoma gene-like 2
PLIN2 perilipin 2
PLK1 polo-like kinase 1
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
PPARG peroxisome proliferator-activated receptor gamma
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PTRH2 peptidyl-tRNA hydrolase 2
RAE1 ribonucleic acid export 1
RBM15 RNA binding motif protein 15
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
RNF139 ring finger protein 139
RNF4 ring finger protein 4
RPP38 ribonuclease P/MRP 38kDa subunit
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RYBP RING1 and YY1 binding protein
SACS sacsin molecular chaperone
SASH1 SAM and SH3 domain containing 1
SCAF8 SR-related CTD-associated factor 8
SCAND1 SCAN domain containing 1
SF3B4 splicing factor 3b, subunit 4, 49kDa
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC38A2 solute carrier family 38, member 2
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCERG1 transcription elongation regulator 1
TEX10 testis expressed 10
TFPI2 tissue factor pathway inhibitor 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF4 transmembrane 4 L six family member 4
TMEM11 transmembrane protein 11
TMEM70 transmembrane protein 70
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNPO1 transportin 1
TOB2 transducer of ERBB2, 2
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TXLNA taxilin alpha
UBAP2L ubiquitin associated protein 2-like
UMPS uridine monophosphate synthetase
USP22 ubiquitin specific peptidase 22
WAPAL wings apart-like homolog (Drosophila)
WDR43 WD repeat domain 43
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZYX zyxin