BRD-K01896723_2-morpholino-N-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

293 genes differentially expressed following the BRD-K01896723_2-morpholino-N-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
ADGRF5 adhesion G protein-coupled receptor F5
ALOX5 arachidonate 5-lipoxygenase
ANXA11 annexin A11
ARL4C ADP-ribosylation factor-like 4C
BSG basigin (Ok blood group)
C3ORF14 chromosome 3 open reading frame 14
CAV1 caveolin 1, caveolae protein, 22kDa
CD47 CD47 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CLIC5 chloride intracellular channel 5
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CRIP2 cysteine-rich protein 2
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DOK5 docking protein 5
DPYD dihydropyrimidine dehydrogenase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHD1 EF-hand domain family, member D1
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO1 enolase 1, (alpha)
EPCAM epithelial cell adhesion molecule
ESRP1 epithelial splicing regulatory protein 1
FLT1 fms-related tyrosine kinase 1
GJA1 gap junction protein, alpha 1, 43kDa
GPM6A glycoprotein M6A
GPX3 glutathione peroxidase 3
GUK1 guanylate kinase 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL7R interleukin 7 receptor
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KDR kinase insert domain receptor
KIAA0226L KIAA0226-like
LAMP2 lysosomal-associated membrane protein 2
LOC100507397 uncharacterized LOC100507397
LTB lymphotoxin beta (TNF superfamily, member 3)
LY96 lymphocyte antigen 96
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MME membrane metallo-endopeptidase
MYOF myoferlin
NEBL nebulette
NMU neuromedin U
NRP1 neuropilin 1
NUPR1 nuclear protein, transcriptional regulator, 1
P3H2 prolyl 3-hydroxylase 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCP4 Purkinje cell protein 4
PODXL podocalyxin-like
PPT1 palmitoyl-protein thioesterase 1
PRKCI protein kinase C, iota
PRSS16 protease, serine, 16 (thymus)
PSENEN presenilin enhancer gamma secretase subunit
PSPH phosphoserine phosphatase
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
PXDN peroxidasin
RGS10 regulator of G-protein signaling 10
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SST somatostatin
STC1 stanniocalcin 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMPRSS3 transmembrane protease, serine 3
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TUSC3 tumor suppressor candidate 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASXL2 additional sex combs like transcriptional regulator 2
ATMIN ATM interactor
AURKA aurora kinase A
AVPI1 arginine vasopressin-induced 1
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BLCAP bladder cancer associated protein
BLM Bloom syndrome, RecQ helicase-like
BRPF1 bromodomain and PHD finger containing, 1
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CEP76 centrosomal protein 76kDa
CHERP calcium homeostasis endoplasmic reticulum protein
CHSY1 chondroitin sulfate synthase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKS2 CDC28 protein kinase regulatory subunit 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRNKL1 crooked neck pre-mRNA splicing factor 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DFNA5 deafness, autosomal dominant 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
ELL2 elongation factor, RNA polymerase II, 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASTKD5 FAST kinase domains 5
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FSCN1 fascin actin-bundling protein 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPATCH8 G patch domain containing 8
GSPT2 G1 to S phase transition 2
GTF2B general transcription factor IIB
H2AFX H2A histone family, member X
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HMOX1 heme oxygenase 1
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IPO7 importin 7
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT17 keratin 17, type I
LAT2 linker for activation of T cells family, member 2
LMO2 LIM domain only 2 (rhombotin-like 1)
LPAR1 lysophosphatidic acid receptor 1
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAK16 MAK16 homolog (S. cerevisiae)
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL2 muscleblind-like splicing regulator 2
MED17 mediator complex subunit 17
MIS12 MIS12 kinetochore complex component
MKI67 marker of proliferation Ki-67
MMD monocyte to macrophage differentiation-associated
MRFAP1L1 Morf4 family associated protein 1-like 1
MSH6 mutS homolog 6
MSL2 male-specific lethal 2 homolog (Drosophila)
MTCL1 microtubule crosslinking factor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NGDN neuroguidin, EIF4E binding protein
NOL11 nucleolar protein 11
NOL8 nucleolar protein 8
NOP56 NOP56 ribonucleoprotein
NRBF2 nuclear receptor binding factor 2
NRIP1 nuclear receptor interacting protein 1
NUP153 nucleoporin 153kDa
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PALB2 partner and localizer of BRCA2
PCNA proliferating cell nuclear antigen
PDS5B PDS5 cohesin associated factor B
PHF20 PHD finger protein 20
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPIF peptidylprolyl isomerase F
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRPF4 pre-mRNA processing factor 4
PRPF4B pre-mRNA processing factor 4B
PTRH2 peptidyl-tRNA hydrolase 2
RAB14 RAB14, member RAS oncogene family
RANBP2 RAN binding protein 2
RANBP6 RAN binding protein 6
RBM12 RNA binding motif protein 12
RBM15 RNA binding motif protein 15
RNF139 ring finger protein 139
RNF6 ring finger protein (C3H2C3 type) 6
RNMT RNA (guanine-7-) methyltransferase
RPL36AL ribosomal protein L36a-like
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SEC24B SEC24 family member B
SECISBP2L SECIS binding protein 2-like
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SETD5 SET domain containing 5
SIRT1 sirtuin 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SMG8 SMG8 nonsense mediated mRNA decay factor
SOX4 SRY (sex determining region Y)-box 4
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRR1A small proline-rich protein 1A
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STIL SCL/TAL1 interrupting locus
STK17A serine/threonine kinase 17a
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBP TATA box binding protein
TBX3 T-box 3
TEX10 testis expressed 10
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM97 transmembrane protein 97
TNPO1 transportin 1
TOB2 transducer of ERBB2, 2
TRAF4 TNF receptor-associated factor 4
TRIM32 tripartite motif containing 32
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
USP6NL USP6 N-terminal like
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3
ZBTB11 zinc finger and BTB domain containing 11
ZMYM2 zinc finger, MYM-type 2
ZNF146 zinc finger protein 146
ZNF189 zinc finger protein 189