BRD-K01896723_2-morpholino-N-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

304 genes differentially expressed following the BRD-K01896723_2-morpholino-N-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACAA2 acetyl-CoA acyltransferase 2
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AEBP1 AE binding protein 1
AIF1 allograft inflammatory factor 1
AK4 adenylate kinase 4
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANOS1 anosmin 1
APLP2 amyloid beta (A4) precursor-like protein 2
APOC1 apolipoprotein C-I
APOOL apolipoprotein O-like
AQP9 aquaporin 9
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C3 complement component 3
C3AR1 complement component 3a receptor 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL20 chemokine (C-C motif) ligand 20
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD163 CD163 molecule
CD177 CD177 molecule
CD38 CD38 molecule
CD53 CD53 molecule
CD9 CD9 molecule
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COLEC12 collectin sub-family member 12
CPB1 carboxypeptidase B1 (tissue)
CPM carboxypeptidase M
CRABP2 cellular retinoic acid binding protein 2
CTSB cathepsin B
CXCL10 chemokine (C-X-C motif) ligand 10
CYBB cytochrome b-245, beta polypeptide
DCN decorin
DENND2D DENN/MADD domain containing 2D
DHCR24 24-dehydrocholesterol reductase
DPYSL3 dihydropyrimidinase-like 3
EIF5A eukaryotic translation initiation factor 5A
ELOVL5 ELOVL fatty acid elongase 5
EMP1 epithelial membrane protein 1
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
FAM198B family with sequence similarity 198, member B
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FILIP1L filamin A interacting protein 1-like
FLT1 fms-related tyrosine kinase 1
FPR1 formyl peptide receptor 1
G0S2 G0/G1 switch 2
GLUL glutamate-ammonia ligase
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GSN gelsolin
HAMP hepcidin antimicrobial peptide
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HPSE heparanase
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
ITM2A integral membrane protein 2A
KIAA0226L KIAA0226-like
LAMA4 laminin, alpha 4
LAPTM5 lysosomal protein transmembrane 5
LPL lipoprotein lipase
LRRC15 leucine rich repeat containing 15
LRRC17 leucine rich repeat containing 17
LTB lymphotoxin beta (TNF superfamily, member 3)
MAGT1 magnesium transporter 1
MAOB monoamine oxidase B
MAPK13 mitogen-activated protein kinase 13
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MT1M metallothionein 1M
NEFH neurofilament, heavy polypeptide
NELL2 NEL-like 2 (chicken)
NID1 nidogen 1
NID2 nidogen 2 (osteonidogen)
NMU neuromedin U
NPY1R neuropeptide Y receptor Y1
ORM1 orosomucoid 1
PDLIM1 PDZ and LIM domain 1
PLA2G12A phospholipase A2, group XIIA
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSPH phosphoserine phosphatase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTRF polymerase I and transcript release factor
PXDN peroxidasin
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RNASE6 ribonuclease, RNase A family, k6
RPRD1A regulation of nuclear pre-mRNA domain containing 1A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG2 secretogranin II
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPB surfactant protein B
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SNX10 sorting nexin 10
SOD2 superoxide dismutase 2, mitochondrial
SPINT1 serine peptidase inhibitor, Kunitz type 1
SRPX sushi-repeat containing protein, X-linked
SULF1 sulfatase 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TDO2 tryptophan 2,3-dioxygenase
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFB3 transforming growth factor, beta 3
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TSPAN13 tetraspanin 13
TTC39A tetratricopeptide repeat domain 39A
VNN1 vanin 1
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
BRPF1 bromodomain and PHD finger containing, 1
C1ORF106 chromosome 1 open reading frame 106
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNE1 cyclin E1
CCNF cyclin F
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHERP calcium homeostasis endoplasmic reticulum protein
CLP1 cleavage and polyadenylation factor I subunit 1
CNOT4 CCR4-NOT transcription complex, subunit 4
COIL coilin
DCLRE1C DNA cross-link repair 1C
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DEFB1 defensin, beta 1
DFNA5 deafness, autosomal dominant 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP22 dual specificity phosphatase 22
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EED embryonic ectoderm development
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F5 coagulation factor V (proaccelerin, labile factor)
FAM102A family with sequence similarity 102, member A
FASTKD5 FAST kinase domains 5
FBL fibrillarin
FOSL1 FOS-like antigen 1
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GRWD1 glutamate-rich WD repeat containing 1
H3F3B H3 histone, family 3B (H3.3B)
HMOX1 heme oxygenase 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HSPA8 heat shock 70kDa protein 8
IER2 immediate early response 2
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
JMJD1C jumonji domain containing 1C
JMJD6 jumonji domain containing 6
JUND jun D proto-oncogene
KANSL2 KAT8 regulatory NSL complex subunit 2
KAT6A K(lysine) acetyltransferase 6A
KEAP1 kelch-like ECH-associated protein 1
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT7 keratin 7, type II
KYNU kynureninase
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAP2K3 mitogen-activated protein kinase kinase 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MARCKS myristoylated alanine-rich protein kinase C substrate
MFSD5 major facilitator superfamily domain containing 5
MID1 midline 1
MIEF1 mitochondrial elongation factor 1
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
MTF2 metal response element binding transcription factor 2
NCALD neurocalcin delta
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFE2L2 nuclear factor, erythroid 2-like 2
NGDN neuroguidin, EIF4E binding protein
NOP16 NOP16 nucleolar protein
NPAS2 neuronal PAS domain protein 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
NXT1 nuclear transport factor 2-like export factor 1
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCGF1 polycomb group ring finger 1
PDGFA platelet-derived growth factor alpha polypeptide
PDS5B PDS5 cohesin associated factor B
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAGL2 pleiomorphic adenoma gene-like 2
PLK1 polo-like kinase 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PSCA prostate stem cell antigen
RAD9A RAD9 homolog A (S. pombe)
RBM14 RNA binding motif protein 14
RBM38 RNA binding motif protein 38
RBM39 RNA binding motif protein 39
RBMS1 RNA binding motif, single stranded interacting protein 1
RGS2 regulator of G-protein signaling 2
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SETD5 SET domain containing 5
SFRP1 secreted frizzled-related protein 1
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SNX11 sorting nexin 11
SPATA2 spermatogenesis associated 2
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC2 transforming, acidic coiled-coil containing protein 2
TBP TATA box binding protein
TGIF1 TGFB-induced factor homeobox 1
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM11 transmembrane protein 11
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TOB1 transducer of ERBB2, 1
TRIM32 tripartite motif containing 32
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TXLNA taxilin alpha
UPK1B uroplakin 1B
USP1 ubiquitin specific peptidase 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VCAN versican
VGLL4 vestigial-like family member 4
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
ZBTB1 zinc finger and BTB domain containing 1
ZCCHC8 zinc finger, CCHC domain containing 8
ZDHHC6 zinc finger, DHHC-type containing 6
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF443 zinc finger protein 443
Funding