BRD-K01896723_2-morpholino-N-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

170 genes differentially expressed following the BRD-K01896723_2-morpholino-N-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
BHLHE40 basic helix-loop-helix family, member e40
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD36 CD36 molecule (thrombospondin receptor)
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CFB complement factor B
CFH complement factor H
CLU clusterin
CPA3 carboxypeptidase A3 (mast cell)
CTGF connective tissue growth factor
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
FBXO11 F-box protein 11
FGFR3 fibroblast growth factor receptor 3
FLT1 fms-related tyrosine kinase 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GPM6A glycoprotein M6A
GPX3 glutathione peroxidase 3
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IER3 immediate early response 3
IFT57 intraflagellar transport 57
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KRT19 keratin 19, type I
MAN1A1 mannosidase, alpha, class 1A, member 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUPR1 nuclear protein, transcriptional regulator, 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK5 proprotein convertase subtilisin/kexin type 5
PLAU plasminogen activator, urokinase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
S100A8 S100 calcium binding protein A8
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SPARCL1 SPARC-like 1 (hevin)
STC1 stanniocalcin 1
TNNT1 troponin T type 1 (skeletal, slow)
TPSAB1 tryptase alpha/beta 1
TSPAN13 tetraspanin 13
VWF von Willebrand factor
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
AP5M1 adaptor-related protein complex 5, mu 1 subunit
ATMIN ATM interactor
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
CCNA2 cyclin A2
CCNF cyclin F
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CHERP calcium homeostasis endoplasmic reticulum protein
CIAPIN1 cytokine induced apoptosis inhibitor 1
CTPS1 CTP synthase 1
DBF4 DBF4 zinc finger
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DIEXF digestive organ expansion factor homolog (zebrafish)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
EED embryonic ectoderm development
EXOSC4 exosome component 4
FASTKD5 FAST kinase domains 5
FBXO28 F-box protein 28
FOSL1 FOS-like antigen 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GOLGA8A golgin A8 family, member A
GRWD1 glutamate-rich WD repeat containing 1
HSPH1 heat shock 105kDa/110kDa protein 1
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0020 KIAA0020
KIAA0907 KIAA0907
KRT7 keratin 7, type II
KYNU kynureninase
LIPT1 lipoyltransferase 1
MAK16 MAK16 homolog (S. cerevisiae)
METTL13 methyltransferase like 13
MGLL monoglyceride lipase
MRPL15 mitochondrial ribosomal protein L15
MTF2 metal response element binding transcription factor 2
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NMD3 NMD3 ribosome export adaptor
NNMT nicotinamide N-methyltransferase
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOL11 nucleolar protein 11
NOP16 NOP16 nucleolar protein
NOP2 NOP2 nucleolar protein
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PDGFA platelet-derived growth factor alpha polypeptide
PELO pelota homolog (Drosophila)
PFKP phosphofructokinase, platelet
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)
PPIF peptidylprolyl isomerase F
PRPF4 pre-mRNA processing factor 4
PTRH2 peptidyl-tRNA hydrolase 2
RFC3 replication factor C (activator 1) 3, 38kDa
RNF4 ring finger protein 4
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
SACS sacsin molecular chaperone
SAP30 Sin3A-associated protein, 30kDa
SCAF8 SR-related CTD-associated factor 8
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMG8 SMG8 nonsense mediated mRNA decay factor
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TBP TATA box binding protein
TEFM transcription elongation factor, mitochondrial
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMX4 thioredoxin-related transmembrane protein 4
TPM4 tropomyosin 4
TRIP6 thyroid hormone receptor interactor 6
UMPS uridine monophosphate synthetase
USP1 ubiquitin specific peptidase 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WDR3 WD repeat domain 3
WDR6 WD repeat domain 6
WDR82 WD repeat domain 82
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZNF146 zinc finger protein 146
ZNF22 zinc finger protein 22