BRD-K01896723_2-morpholino-N-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

265 genes differentially expressed following the BRD-K01896723_2-morpholino-N-((5-nitro-1H-benzo[d]imidazol-2-yl)methyl)-9-(thiophen-3-yl)-9H-purin-6-amine_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAMDEC1 ADAM-like, decysin 1
ADGRL4 adhesion G protein-coupled receptor L4
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
ANXA9 annexin A9
AQP9 aquaporin 9
ARMCX1 armadillo repeat containing, X-linked 1
ASPN asporin
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
BLNK B-cell linker
BTG2 BTG family, member 2
CCL4 chemokine (C-C motif) ligand 4
CD14 CD14 molecule
CD163 CD163 molecule
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CLEC10A C-type lectin domain family 10, member A
CLEC7A C-type lectin domain family 7, member A
COL1A2 collagen, type I, alpha 2
CPE carboxypeptidase E
CPQ carboxypeptidase Q
CRABP2 cellular retinoic acid binding protein 2
CTSV cathepsin V
CTSZ cathepsin Z
CXCL2 chemokine (C-X-C motif) ligand 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYBB cytochrome b-245, beta polypeptide
DACH1 dachshund family transcription factor 1
DEFA4 defensin, alpha 4, corticostatin
DKK3 dickkopf WNT signaling pathway inhibitor 3
EGR1 early growth response 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
ESRP1 epithelial splicing regulatory protein 1
EXT1 exostosin glycosyltransferase 1
F11R F11 receptor
F13A1 coagulation factor XIII, A1 polypeptide
FAM198B family with sequence similarity 198, member B
FAM49A family with sequence similarity 49, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGL2 fibrinogen-like 2
FHOD3 formin homology 2 domain containing 3
FLT1 fms-related tyrosine kinase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FRY furry homolog (Drosophila)
FXYD6 FXYD domain containing ion transport regulator 6
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GAS6 growth arrest-specific 6
GATA6 GATA binding protein 6
GCLC glutamate-cysteine ligase, catalytic subunit
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GPRASP1 G protein-coupled receptor associated sorting protein 1
HCAR3 hydroxycarboxylic acid receptor 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGSF6 immunoglobulin superfamily, member 6
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IQGAP1 IQ motif containing GTPase activating protein 1
IRF6 interferon regulatory factor 6
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
JUNB jun B proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCTD12 potassium channel tetramerization domain containing 12
KCTD14 potassium channel tetramerization domain containing 14
KIAA1462 KIAA1462
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LPPR4 lipid phosphate phosphatase-related protein type 4
LYZ lysozyme
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MOXD1 monooxygenase, DBH-like 1
MPO myeloperoxidase
MPZL2 myelin protein zero-like 2
MTSS1 metastasis suppressor 1
MXRA5 matrix-remodelling associated 5
NR4A2 nuclear receptor subfamily 4, group A, member 2
OSBPL1A oxysterol binding protein-like 1A
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCDH7 protocadherin 7
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLBD1 phospholipase B domain containing 1
PLN phospholamban
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRSS16 protease, serine, 16 (thymus)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTPRO protein tyrosine phosphatase, receptor type, O
PYCARD PYD and CARD domain containing
RAB25 RAB25, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCARB2 scavenger receptor class B, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SMC1A structural maintenance of chromosomes 1A
SOX17 SRY (sex determining region Y)-box 17
SPINT1 serine peptidase inhibitor, Kunitz type 1
STC1 stanniocalcin 1
SULF1 sulfatase 1
SUSD4 sushi domain containing 4
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TEK TEK tyrosine kinase, endothelial
TF transferrin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMEM30B transmembrane protein 30B
TMEM35 transmembrane protein 35
TNNT1 troponin T type 1 (skeletal, slow)
TRIB1 tribbles pseudokinase 1
TSPAN7 tetraspanin 7
TYROBP TYRO protein tyrosine kinase binding protein
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT5B wingless-type MMTV integration site family, member 5B
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACTN1 actinin, alpha 1
ADGRG6 adhesion G protein-coupled receptor G6
AK1 adenylate kinase 1
AKAP7 A kinase (PRKA) anchor protein 7
ALCAM activated leukocyte cell adhesion molecule
AMD1 adenosylmethionine decarboxylase 1
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX6 armadillo repeat containing, X-linked 6
ARPC5L actin related protein 2/3 complex, subunit 5-like
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BLMH bleomycin hydrolase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTBD3 BTB (POZ) domain containing 3
BUB3 BUB3 mitotic checkpoint protein
CCNA2 cyclin A2
CD99 CD99 molecule
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CHERP calcium homeostasis endoplasmic reticulum protein
CHPT1 choline phosphotransferase 1
CLIC4 chloride intracellular channel 4
CXCL14 chemokine (C-X-C motif) ligand 14
CYTL1 cytokine-like 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
DYNLL1 dynein, light chain, LC8-type 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5A eukaryotic translation initiation factor 5A
EPS8 epidermal growth factor receptor pathway substrate 8
FAM13A family with sequence similarity 13, member A
FAM35A family with sequence similarity 35, member A
FOLR1 folate receptor 1 (adult)
FOXJ3 forkhead box J3
GRWD1 glutamate-rich WD repeat containing 1
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HPCAL1 hippocalcin-like 1
HSPA8 heat shock 70kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KDM5D lysine (K)-specific demethylase 5D
KRT10 keratin 10, type I
KRT7 keratin 7, type II
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LIMCH1 LIM and calponin homology domains 1
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NFIB nuclear factor I/B
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NNMT nicotinamide N-methyltransferase
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOSIP nitric oxide synthase interacting protein
NPY neuropeptide Y
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PBK PDZ binding kinase
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PMP22 peripheral myelin protein 22
PPARG peroxisome proliferator-activated receptor gamma
PRDX1 peroxiredoxin 1
PRKCA protein kinase C, alpha
PRPF4 pre-mRNA processing factor 4
RAB13 RAB13, member RAS oncogene family
RAE1 ribonucleic acid export 1
RNF167 ring finger protein 167
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
RPS26 ribosomal protein S26
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RUVBL1 RuvB-like AAA ATPase 1
SACS sacsin molecular chaperone
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SRPX sushi-repeat containing protein, X-linked
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFB2M transcription factor B2, mitochondrial
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TM9SF3 transmembrane 9 superfamily member 3
TMEM2 transmembrane protein 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNPO1 transportin 1
TSC22D1 TSC22 domain family, member 1
TTF1 transcription termination factor, RNA polymerase I
TUBB6 tubulin, beta 6 class V
TXLNA taxilin alpha
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2S ubiquitin-conjugating enzyme E2S
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WWTR1 WW domain containing transcription regulator 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZBTB18 zinc finger and BTB domain containing 18