BRD-K01868942_3-(piperidin-1-yl)propyl-4-amino-5-chloro-2methoxybenzoate . Hydrochloride_VCAP_6.0_h_160.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K01868942_3-(piperidin-1-yl)propyl-4-amino-5-chloro-2methoxybenzoate . Hydrochloride_VCAP_6.0_h_160.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACKR3 atypical chemokine receptor 3
ACSL3 acyl-CoA synthetase long-chain family member 3
ARL4C ADP-ribosylation factor-like 4C
ARMCX1 armadillo repeat containing, X-linked 1
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR7 7-dehydrocholesterol reductase
DPP4 dipeptidyl-peptidase 4
EBP emopamil binding protein (sterol isomerase)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAM129A family with sequence similarity 129, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
HAL histidine ammonia-lyase
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KIAA0355 KIAA0355
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MSMO1 methylsterol monooxygenase 1
MT1G metallothionein 1G
NSDHL NAD(P) dependent steroid dehydrogenase-like
PDE2A phosphodiesterase 2A, cGMP-stimulated
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SQLE squalene epoxidase
TIMP1 TIMP metallopeptidase inhibitor 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADGRE5 adhesion G protein-coupled receptor E5
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASS1 argininosuccinate synthase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BST2 bone marrow stromal cell antigen 2
C1QTNF3 C1q and tumor necrosis factor related protein 3
COL11A1 collagen, type XI, alpha 1
CP ceruloplasmin (ferroxidase)
CRIP1 cysteine-rich protein 1 (intestinal)
CTSC cathepsin C
EPCAM epithelial cell adhesion molecule
GOLGA8A golgin A8 family, member A
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LEF1 lymphoid enhancer-binding factor 1
LUM lumican
MTUS1 microtubule associated tumor suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFL neurofilament, light polypeptide
NID2 nidogen 2 (osteonidogen)
RPS11 ribosomal protein S11
SLPI secretory leukocyte peptidase inhibitor
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SOX11 SRY (sex determining region Y)-box 11
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SULF1 sulfatase 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TSPYL5 TSPY-like 5
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)