BRD-K01868942_3-(piperidin-1-yl)propyl-4-amino-5-chloro-2methoxybenzoate . Hydrochloride_THP1_6.0_h_160.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

117 genes differentially expressed following the BRD-K01868942_3-(piperidin-1-yl)propyl-4-amino-5-chloro-2methoxybenzoate . Hydrochloride_THP1_6.0_h_160.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
AMIGO2 adhesion molecule with Ig-like domain 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
C10ORF10 chromosome 10 open reading frame 10
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD93 CD93 molecule
CLEC2B C-type lectin domain family 2, member B
CLIC2 chloride intracellular channel 2
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
EDN1 endothelin 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EPAS1 endothelial PAS domain protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F11R F11 receptor
FGL2 fibrinogen-like 2
FILIP1L filamin A interacting protein 1-like
FLT1 fms-related tyrosine kinase 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GSTA1 glutathione S-transferase alpha 1
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDO1 indoleamine 2,3-dioxygenase 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP5 insulin-like growth factor binding protein 5
INA internexin neuronal intermediate filament protein, alpha
KCNK3 potassium channel, two pore domain subfamily K, member 3
LDOC1 leucine zipper, down-regulated in cancer 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR6 lysophosphatidic acid receptor 6
MKNK1 MAP kinase interacting serine/threonine kinase 1
NARFL nuclear prelamin A recognition factor-like
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NVL nuclear VCP-like
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE2A phosphodiesterase 2A, cGMP-stimulated
PEG10 paternally expressed 10
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLVAP plasmalemma vesicle associated protein
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
PTHLH parathyroid hormone-like hormone
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SHB Src homology 2 domain containing adaptor protein B
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SPON1 spondin 1, extracellular matrix protein
SSPN sarcospan
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TBXA2R thromboxane A2 receptor
TCF4 transcription factor 4
TES testin LIM domain protein
TESK1 testis-specific kinase 1
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM30B transmembrane protein 30B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
VEGFA vascular endothelial growth factor A
VSNL1 visinin-like 1
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACSL1 acyl-CoA synthetase long-chain family member 1
AKAP12 A kinase (PRKA) anchor protein 12
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
BAG2 BCL2-associated athanogene 2
BASP1 brain abundant, membrane attached signal protein 1
CHI3L2 chitinase 3-like 2
CPD carboxypeptidase D
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
EDF1 endothelial differentiation-related factor 1
FKBP11 FK506 binding protein 11, 19 kDa
FSTL1 follistatin-like 1
GLB1 galactosidase, beta 1
GOLM1 golgi membrane protein 1
HOMER1 homer scaffolding protein 1
IQGAP2 IQ motif containing GTPase activating protein 2
JMJD6 jumonji domain containing 6
LRRC59 leucine rich repeat containing 59
LTF lactotransferrin
MAGED1 melanoma antigen family D1
MXRA7 matrix-remodelling associated 7
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa
PDGFC platelet derived growth factor C
PDLIM5 PDZ and LIM domain 5
PLIN3 perilipin 3
PRDX2 peroxiredoxin 2
PRKCB protein kinase C, beta
PRPF4 pre-mRNA processing factor 4
PTCH1 patched 1
PTX3 pentraxin 3, long
RAD23B RAD23 homolog B (S. cerevisiae)
RBP1 retinol binding protein 1, cellular
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL36 ribosomal protein L36
SRSF6 serine/arginine-rich splicing factor 6
STXBP2 syntaxin binding protein 2
TUBB6 tubulin, beta 6 class V
UBE2E1 ubiquitin-conjugating enzyme E2E 1