BRD-K01868942_3-(piperidin-1-yl)propyl-4-amino-5-chloro-2methoxybenzoate . Hydrochloride_HT115_6.0_h_160.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-K01868942_3-(piperidin-1-yl)propyl-4-amino-5-chloro-2methoxybenzoate . Hydrochloride_HT115_6.0_h_160.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
C3ORF14 chromosome 3 open reading frame 14
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CD24 CD24 molecule
CD9 CD9 molecule
CHN1 chimerin 1
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CSNK2A2 casein kinase 2, alpha prime polypeptide
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSC2 desmocollin 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EMP1 epithelial membrane protein 1
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
GPNMB glycoprotein (transmembrane) nmb
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GSDMB gasdermin B
HOPX HOP homeobox
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTRA1 HtrA serine peptidase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL13RA1 interleukin 13 receptor, alpha 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLF11 Kruppel-like factor 11
LOXL2 lysyl oxidase-like 2
MAN1A1 mannosidase, alpha, class 1A, member 1
MGP matrix Gla protein
MICALL1 MICAL-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MYBPC1 myosin binding protein C, slow type
NEBL nebulette
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NUP85 nucleoporin 85kDa
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PBX1 pre-B-cell leukemia homeobox 1
PBX3 pre-B-cell leukemia homeobox 3
PEG10 paternally expressed 10
POSTN periostin, osteoblast specific factor
PPOX protoporphyrinogen oxidase
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGCC regulator of cell cycle
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRM2 ribonucleotide reductase M2
RTN2 reticulon 2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A1 solute carrier family 38, member 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SULF1 sulfatase 1
TBX3 T-box 3
TESK1 testis-specific kinase 1
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TRIB3 tribbles pseudokinase 3
TRIL TLR4 interactor with leucine-rich repeats
TXNIP thioredoxin interacting protein
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AQP3 aquaporin 3 (Gill blood group)
BAD BCL2-associated agonist of cell death
C1S complement component 1, s subcomponent
CD59 CD59 molecule, complement regulatory protein
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CP ceruloplasmin (ferroxidase)
CRIP1 cysteine-rich protein 1 (intestinal)
CSRP1 cysteine and glycine-rich protein 1
CTSZ cathepsin Z
CXCL14 chemokine (C-X-C motif) ligand 14
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
EI24 etoposide induced 2.4
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPS8 epidermal growth factor receptor pathway substrate 8
FGF9 fibroblast growth factor 9
FOLR1 folate receptor 1 (adult)
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
H2BFS H2B histone family, member S (pseudogene)
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
IGHM immunoglobulin heavy constant mu
ITGA6 integrin, alpha 6
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KDM5D lysine (K)-specific demethylase 5D
LAPTM4B lysosomal protein transmembrane 4 beta
MALL mal, T-cell differentiation protein-like
MARCKS myristoylated alanine-rich protein kinase C substrate
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MPPED2 metallophosphoesterase domain containing 2
MTERF3 mitochondrial transcription termination factor 3
MVP major vault protein
NUP98 nucleoporin 98kDa
PAPOLA poly(A) polymerase alpha
PFN2 profilin 2
PIR pirin (iron-binding nuclear protein)
PLBD1 phospholipase B domain containing 1
PTDSS1 phosphatidylserine synthase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
RBP1 retinol binding protein 1, cellular
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC46A3 solute carrier family 46, member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TM4SF1 transmembrane 4 L six family member 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAM1 vascular cell adhesion molecule 1
VGLL4 vestigial-like family member 4
WFDC2 WAP four-disulfide core domain 2