BRD-K01436366_XMD-1150_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K01436366_XMD-1150_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABHD6 abhydrolase domain containing 6
ALCAM activated leukocyte cell adhesion molecule
CAST calpastatin
CES1 carboxylesterase 1
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EFNB2 ephrin-B2
ERBB2 erb-b2 receptor tyrosine kinase 2
GNAS GNAS complex locus
HIST1H1C histone cluster 1, H1c
HYAL1 hyaluronoglucosaminidase 1
IGHD immunoglobulin heavy constant delta
LDOC1 leucine zipper, down-regulated in cancer 1
LIMCH1 LIM and calponin homology domains 1
MYO6 myosin VI
NDRG4 NDRG family member 4
PRAF2 PRA1 domain family, member 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
REEP1 receptor accessory protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
TRAM2 translocation associated membrane protein 2
VNN1 vanin 1
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ANPEP alanyl (membrane) aminopeptidase
BRCA1 breast cancer 1, early onset
CAV1 caveolin 1, caveolae protein, 22kDa
CCR7 chemokine (C-C motif) receptor 7
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
COCH cochlin
CRISP3 cysteine-rich secretory protein 3
DDB2 damage-specific DNA binding protein 2, 48kDa
DEK DEK proto-oncogene
EFS embryonal Fyn-associated substrate
FAM57A family with sequence similarity 57, member A
FBLN1 fibulin 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GREB1 growth regulation by estrogen in breast cancer 1
ICAM3 intercellular adhesion molecule 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITM2A integral membrane protein 2A
JADE2 jade family PHD finger 2
KLK11 kallikrein-related peptidase 11
LEF1 lymphoid enhancer-binding factor 1
LOXL1 lysyl oxidase-like 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAL mal, T-cell differentiation protein
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MUC1 mucin 1, cell surface associated
MYO5C myosin VC
PARP2 poly (ADP-ribose) polymerase 2
PDGFC platelet derived growth factor C
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPARG peroxisome proliferator-activated receptor gamma
PPIF peptidylprolyl isomerase F
PRIM1 primase, DNA, polypeptide 1 (49kDa)
RAB25 RAB25, member RAS oncogene family
RHOBTB3 Rho-related BTB domain containing 3
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TFF3 trefoil factor 3 (intestinal)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
ZWINT ZW10 interacting kinetochore protein