BRD-K01436366_XMD-1150_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

204 genes differentially expressed following the BRD-K01436366_XMD-1150_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMIGO2 adhesion molecule with Ig-like domain 2
ARMCX2 armadillo repeat containing, X-linked 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAMBI BMP and activin membrane-bound inhibitor
BEX1 brain expressed, X-linked 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BST2 bone marrow stromal cell antigen 2
CAPG capping protein (actin filament), gelsolin-like
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDR2L cerebellar degeneration-related protein 2-like
COL4A5 collagen, type IV, alpha 5
CREB1 cAMP responsive element binding protein 1
CTSB cathepsin B
CXADR coxsackie virus and adenovirus receptor
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPYSL2 dihydropyrimidinase-like 2
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFNA1 ephrin-A1
EFNB2 ephrin-B2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL5 ELOVL fatty acid elongase 5
ENAH enabled homolog (Drosophila)
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FAM50A family with sequence similarity 50, member A
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXF1 forkhead box F1
G6PD glucose-6-phosphate dehydrogenase
GDI1 GDP dissociation inhibitor 1
GLRX glutaredoxin (thioltransferase)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX1 glutathione peroxidase 1
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI6 interferon, alpha-inducible protein 6
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KIF2C kinesin family member 2C
KTN1 kinectin 1 (kinesin receptor)
LAMP2 lysosomal-associated membrane protein 2
LDOC1 leucine zipper, down-regulated in cancer 1
LXN latexin
LYPD1 LY6/PLAUR domain containing 1
MSLN mesothelin
MTMR11 myotubularin related protein 11
MVP major vault protein
MYO6 myosin VI
NDRG1 N-myc downstream regulated 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OSBPL10 oxysterol binding protein-like 10
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PALLD palladin, cytoskeletal associated protein
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PEG10 paternally expressed 10
PFKM phosphofructokinase, muscle
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLA2G15 phospholipase A2, group XV
PRAF2 PRA1 domain family, member 2
PRDX1 peroxiredoxin 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PXDN peroxidasin
RAB5B RAB5B, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RGS16 regulator of G-protein signaling 16
ROGDI rogdi homolog (Drosophila)
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN3 reticulon 3
S100A4 S100 calcium binding protein A4
SC5D sterol-C5-desaturase
SCPEP1 serine carboxypeptidase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SIK1 salt-inducible kinase 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SRGN serglycin
SSR4 signal sequence receptor, delta
STXBP1 syntaxin binding protein 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM7SF2 transmembrane 7 superfamily member 2
TMEM2 transmembrane protein 2
TUBA1A tubulin, alpha 1a
USP9X ubiquitin specific peptidase 9, X-linked
VAT1 vesicle amine transport 1
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOE apolipoprotein E
AQP3 aquaporin 3 (Gill blood group)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BLMH bleomycin hydrolase
BTG3 BTG family, member 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C3ORF14 chromosome 3 open reading frame 14
CCNA2 cyclin A2
CCND2 cyclin D2
CDC25A cell division cycle 25A
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMD dystrophin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
FAM129A family with sequence similarity 129, member A
FAS Fas cell surface death receptor
FEN1 flap structure-specific endonuclease 1
FGF13 fibroblast growth factor 13
FOXM1 forkhead box M1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GBP1 guanylate binding protein 1, interferon-inducible
GGCT gamma-glutamylcyclotransferase
GLUL glutamate-ammonia ligase
GNPDA1 glucosamine-6-phosphate deaminase 1
GTSE1 G-2 and S-phase expressed 1
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
IARS isoleucyl-tRNA synthetase
IFI44 interferon-induced protein 44
IFRD2 interferon-related developmental regulator 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
LMNB1 lamin B1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPK13 mitogen-activated protein kinase 13
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MMP9 matrix metallopeptidase 9
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
OIP5 Opa interacting protein 5
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCOLCE procollagen C-endopeptidase enhancer
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
POSTN periostin, osteoblast specific factor
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RAD51C RAD51 paralog C
RFC3 replication factor C (activator 1) 3, 38kDa
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SNAI2 snail family zinc finger 2
SPATS2L spermatogenesis associated, serine-rich 2-like
SPC25 SPC25, NDC80 kinetochore complex component
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TDO2 tryptophan 2,3-dioxygenase
TEX30 testis expressed 30
TFAM transcription factor A, mitochondrial
TNC tenascin C
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN4 tetraspanin 4
TWIST1 twist family bHLH transcription factor 1
UBE2C ubiquitin-conjugating enzyme E2C
ZNF22 zinc finger protein 22