BRD-K01436366_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-K01436366_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA1 acetyl-CoA acyltransferase 1
ALOX15B arachidonate 15-lipoxygenase, type B
APLP2 amyloid beta (A4) precursor-like protein 2
C3ORF14 chromosome 3 open reading frame 14
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNG2 cyclin G2
CD24 CD24 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CNTNAP2 contactin associated protein-like 2
COL11A1 collagen, type XI, alpha 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB5R1 cytochrome b5 reductase 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BK histone cluster 1, H2bk
HK1 hexokinase 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
KLK6 kallikrein-related peptidase 6
KRT7 keratin 7, type II
LAMP2 lysosomal-associated membrane protein 2
MAP7 microtubule-associated protein 7
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
NEBL nebulette
NMU neuromedin U
NSDHL NAD(P) dependent steroid dehydrogenase-like
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PSAP prosaposin
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
STXBP1 syntaxin binding protein 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM165 transmembrane protein 165
TST thiosulfate sulfurtransferase (rhodanese)
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ATF3 activating transcription factor 3
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCDC86 coiled-coil domain containing 86
CD44 CD44 molecule (Indian blood group)
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
CP ceruloplasmin (ferroxidase)
F3 coagulation factor III (thromboplastin, tissue factor)
FCGBP Fc fragment of IgG binding protein
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOXB7 homeobox B7
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
LAMC1 laminin, gamma 1 (formerly LAMB2)
MECOM MDS1 and EVI1 complex locus
MSX1 msh homeobox 1
NMI N-myc (and STAT) interactor
PHLDA1 pleckstrin homology-like domain, family A, member 1
PRAME preferentially expressed antigen in melanoma
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
REG1A regenerating islet-derived 1 alpha
RPIA ribose 5-phosphate isomerase A
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SORBS3 sorbin and SH3 domain containing 3
SPATS2L spermatogenesis associated, serine-rich 2-like
SPINK1 serine peptidase inhibitor, Kazal type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
UBE2E3 ubiquitin-conjugating enzyme E2E 3
ZIC1 Zic family member 1