BRD-K01121114_AT-MLPCN CSC-006_SKM1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-K01121114_AT-MLPCN CSC-006_SKM1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AKR1C2 aldo-keto reductase family 1, member C2
ANXA3 annexin A3
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
AUTS2 autism susceptibility candidate 2
BTG1 B-cell translocation gene 1, anti-proliferative
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBS cystathionine-beta-synthase
CD24 CD24 molecule
CELF2 CUGBP, Elav-like family member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC4 chloride intracellular channel 4
CP ceruloplasmin (ferroxidase)
CPA3 carboxypeptidase A3 (mast cell)
CXCR4 chemokine (C-X-C motif) receptor 4
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDIT4 DNA-damage-inducible transcript 4
DOCK4 dedicator of cytokinesis 4
EPAS1 endothelial PAS domain protein 1
EREG epiregulin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EZR ezrin
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
HIPK1 homeodomain interacting protein kinase 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HSPA13 heat shock protein 70kDa family, member 13
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
KRT23 keratin 23, type I
LITAF lipopolysaccharide-induced TNF factor
LMO3 LIM domain only 3 (rhombotin-like 2)
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MOCOS molybdenum cofactor sulfurase
MPZL2 myelin protein zero-like 2
MYO1D myosin ID
NEBL nebulette
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHACTR2 phosphatase and actin regulator 2
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSAT1 phosphoserine aminotransferase 1
PTN pleiotrophin
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SASH1 SAM and SH3 domain containing 1
SDC2 syndecan 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX7 sorting nexin 7
SPON1 spondin 1, extracellular matrix protein
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TES testin LIM domain protein
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM47 transmembrane protein 47
TNC tenascin C
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WARS tryptophanyl-tRNA synthetase
WSB1 WD repeat and SOCS box containing 1
YARS tyrosyl-tRNA synthetase
ZHX2 zinc fingers and homeoboxes 2

decreased expression

Symbol Name
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COL6A1 collagen, type VI, alpha 1
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSA cathepsin A
EGR3 early growth response 3
FASTKD5 FAST kinase domains 5
GNAS GNAS complex locus
GSTP1 glutathione S-transferase pi 1
HN1L hematological and neurological expressed 1-like
HSPA1A heat shock 70kDa protein 1A
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IFI30 interferon, gamma-inducible protein 30
JMJD6 jumonji domain containing 6
KCTD12 potassium channel tetramerization domain containing 12
KIF5C kinesin family member 5C
LAPTM4B lysosomal protein transmembrane 4 beta
LAT2 linker for activation of T cells family, member 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA1 melanoma antigen family A1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA5 melanoma antigen family A5
MAGEA6 melanoma antigen family A6
MAMLD1 mastermind-like domain containing 1
MXRA7 matrix-remodelling associated 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NSDHL NAD(P) dependent steroid dehydrogenase-like
NSG1 neuron specific gene family member 1
OAT ornithine aminotransferase
ODAM odontogenic, ameloblast asssociated
PCOLCE2 procollagen C-endopeptidase enhancer 2
PNP purine nucleoside phosphorylase
PRDX1 peroxiredoxin 1
RASA4 RAS p21 protein activator 4
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A10 S100 calcium binding protein A10
SCPEP1 serine carboxypeptidase 1
SELL selectin L
SFRP1 secreted frizzled-related protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SORD sorbitol dehydrogenase
STXBP2 syntaxin binding protein 2
TLR4 toll-like receptor 4
TMEM255A transmembrane protein 255A
TNS1 tensin 1
TSPAN8 tetraspanin 8
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
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