BRD-K01121114_AT-MLPCN CSC-006_PL21_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-K01121114_AT-MLPCN CSC-006_PL21_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AARS alanyl-tRNA synthetase
ALOX5 arachidonate 5-lipoxygenase
ANXA3 annexin A3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF5 activating transcription factor 5
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BGN biglycan
BTG3 BTG family, member 3
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD163 CD163 molecule
CD24 CD24 molecule
CDC5L cell division cycle 5-like
CEMIP cell migration inducing protein, hyaluronan binding
CLEC2B C-type lectin domain family 2, member B
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EIF5 eukaryotic translation initiation factor 5
FAM129A family with sequence similarity 129, member A
G0S2 G0/G1 switch 2
GDF15 growth differentiation factor 15
GPNMB glycoprotein (transmembrane) nmb
GUSBP11 glucuronidase, beta pseudogene 11
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HP haptoglobin
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IGLV1-40 immunoglobulin lambda variable 1-40
IGLV3-19 immunoglobulin lambda variable 3-19
ITM2A integral membrane protein 2A
KRT7 keratin 7, type II
KYNU kynureninase
LAMP3 lysosomal-associated membrane protein 3
LMO3 LIM domain only 3 (rhombotin-like 2)
LTF lactotransferrin
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha)
MEST mesoderm specific transcript
MGLL monoglyceride lipase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTUS1 microtubule associated tumor suppressor 1
NAMPT nicotinamide phosphoribosyltransferase
NEB nebulin
NEFM neurofilament, medium polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
OXTR oxytocin receptor
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG10 paternally expressed 10
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PSAT1 phosphoserine aminotransferase 1
RAD51AP1 RAD51 associated protein 1
RBBP8 retinoblastoma binding protein 8
RBM47 RNA binding motif protein 47
RGCC regulator of cell cycle
RHOBTB3 Rho-related BTB domain containing 3
RIOK3 RIO kinase 3
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNX10 sorting nexin 10
SOD2 superoxide dismutase 2, mitochondrial
SPATS2L spermatogenesis associated, serine-rich 2-like
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TBC1D31 TBC1 domain family, member 31
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TP53 tumor protein p53
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
WARS tryptophanyl-tRNA synthetase
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
BCHE butyrylcholinesterase
BEX1 brain expressed, X-linked 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CD200 CD200 molecule
CX3CR1 chemokine (C-X3-C motif) receptor 1
DACH1 dachshund family transcription factor 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFA5 defensin, alpha 5, Paneth cell-specific
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EBP emopamil binding protein (sterol isomerase)
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4A1 eukaryotic translation initiation factor 4A1
ELF1 E74-like factor 1 (ets domain transcription factor)
ENO2 enolase 2 (gamma, neuronal)
FAM98A family with sequence similarity 98, member A
FCGBP Fc fragment of IgG binding protein
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HES1 hes family bHLH transcription factor 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
LDLR low density lipoprotein receptor
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LTBP1 latent transforming growth factor beta binding protein 1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
NOTCH2 notch 2
NT5DC2 5'-nucleotidase domain containing 2
PNP purine nucleoside phosphorylase
PTP4A2 protein tyrosine phosphatase type IVA, member 2
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SRSF2 serine/arginine-rich splicing factor 2
SRSF5 serine/arginine-rich splicing factor 5
SST somatostatin
TFF1 trefoil factor 1
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM97 transmembrane protein 97
UBL3 ubiquitin-like 3