BRD-K01121114_AT-MLPCN CSC-006_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

53 genes differentially expressed following the BRD-K01121114_AT-MLPCN CSC-006_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCL20 chemokine (C-C motif) ligand 20
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CXCL2 chemokine (C-X-C motif) ligand 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
FAM129A family with sequence similarity 129, member A
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
H1F0 H1 histone family, member 0
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
LMO4 LIM domain only 4
LPL lipoprotein lipase
MOCOS molybdenum cofactor sulfurase
MYC v-myc avian myelocytomatosis viral oncogene homolog
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PELI1 pellino E3 ubiquitin protein ligase 1
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STEAP1 six transmembrane epithelial antigen of the prostate 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ATF5 activating transcription factor 5
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
EFHD1 EF-hand domain family, member D1
FGFR3 fibroblast growth factor receptor 3
GRB7 growth factor receptor-bound protein 7
HBB hemoglobin, beta
HSPA1A heat shock 70kDa protein 1A
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP5 microfibrillar associated protein 5
PMP22 peripheral myelin protein 22
S100A8 S100 calcium binding protein A8
SRGN serglycin
TIMP3 TIMP metallopeptidase inhibitor 3