BRD-K01121114_AT-MLPCN CSC-006_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-K01121114_AT-MLPCN CSC-006_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ADIRF adipogenesis regulatory factor
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CLDN7 claudin 7
CRABP1 cellular retinoic acid binding protein 1
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
EFS embryonal Fyn-associated substrate
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FBN2 fibrillin 2
GDF15 growth differentiation factor 15
GTPBP2 GTP binding protein 2
HSPA1A heat shock 70kDa protein 1A
IARS isoleucyl-tRNA synthetase
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IFRD1 interferon-related developmental regulator 1
LPL lipoprotein lipase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MME membrane metallo-endopeptidase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NARS asparaginyl-tRNA synthetase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NKG7 natural killer cell granule protein 7
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RTCA RNA 3'-terminal phosphate cyclase
SARS seryl-tRNA synthetase
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
TERF2IP telomeric repeat binding factor 2, interacting protein
TRIB3 tribbles pseudokinase 3
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
TXNRD1 thioredoxin reductase 1
WARS tryptophanyl-tRNA synthetase
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
ZIC1 Zic family member 1

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADM adrenomedullin
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANGPT1 angiopoietin 1
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA9 carbonic anhydrase IX
CCL2 chemokine (C-C motif) ligand 2
CD58 CD58 molecule
CHERP calcium homeostasis endoplasmic reticulum protein
CKB creatine kinase, brain
CLINT1 clathrin interactor 1
COL5A1 collagen, type V, alpha 1
COL6A1 collagen, type VI, alpha 1
CSRP2 cysteine and glycine-rich protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DPYSL3 dihydropyrimidinase-like 3
EBP emopamil binding protein (sterol isomerase)
EGLN3 egl-9 family hypoxia-inducible factor 3
EMP2 epithelial membrane protein 2
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
ERAP2 endoplasmic reticulum aminopeptidase 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM162A family with sequence similarity 162, member A
FGFR3 fibroblast growth factor receptor 3
FZD7 frizzled class receptor 7
GATA6 GATA binding protein 6
GJA1 gap junction protein, alpha 1, 43kDa
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRWD1 glutamate-rich WD repeat containing 1
GSTM3 glutathione S-transferase mu 3 (brain)
H3F3B H3 histone, family 3B (H3.3B)
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2BK histone cluster 1, H2bk
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP3 insulin-like growth factor binding protein 3
IGSF3 immunoglobulin superfamily, member 3
INSIG1 insulin induced gene 1
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDM4B lysine (K)-specific demethylase 4B
KIF20A kinesin family member 20A
KLF10 Kruppel-like factor 10
LDLR low density lipoprotein receptor
LOXL1 lysyl oxidase-like 1
LRRC59 leucine rich repeat containing 59
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LYPD1 LY6/PLAUR domain containing 1
MAN1A1 mannosidase, alpha, class 1A, member 1
NDRG1 N-myc downstream regulated 1
NNMT nicotinamide N-methyltransferase
NREP neuronal regeneration related protein
NRN1 neuritin 1
OAT ornithine aminotransferase
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PKM pyruvate kinase, muscle
PLAT plasminogen activator, tissue
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMEPA1 prostate transmembrane protein, androgen induced 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAME preferentially expressed antigen in melanoma
PRSS2 protease, serine, 2 (trypsin 2)
PRSS23 protease, serine, 23
QPCT glutaminyl-peptide cyclotransferase
RHOB ras homolog family member B
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPAG4 sperm associated antigen 4
SQLE squalene epoxidase
TFF1 trefoil factor 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
VCAM1 vascular cell adhesion molecule 1
WFDC2 WAP four-disulfide core domain 2
WNT5A wingless-type MMTV integration site family, member 5A
ZMIZ1 zinc finger, MIZ-type containing 1