BRD-K01121114_AT-MLPCN CSC-006_AGS_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K01121114_AT-MLPCN CSC-006_AGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOB aldolase B, fructose-bisphosphate
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE41 basic helix-loop-helix family, member e41
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CEP57 centrosomal protein 57kDa
CFI complement factor I
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHN1 chimerin 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLCA4 chloride channel accessory 4
COL11A1 collagen, type XI, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
CSRP2 cysteine and glycine-rich protein 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
ECM1 extracellular matrix protein 1
FAIM Fas apoptotic inhibitory molecule
FBP1 fructose-1,6-bisphosphatase 1
FBXO11 F-box protein 11
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
GUSBP11 glucuronidase, beta pseudogene 11
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
IPO13 importin 13
ITM2C integral membrane protein 2C
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
LEF1 lymphoid enhancer-binding factor 1
LOXL2 lysyl oxidase-like 2
MEIS2 Meis homeobox 2
METRN meteorin, glial cell differentiation regulator
MOK MOK protein kinase
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
PODXL podocalyxin-like
REG1A regenerating islet-derived 1 alpha
RGCC regulator of cell cycle
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
S100A8 S100 calcium binding protein A8
SATB1 SATB homeobox 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SSPN sarcospan
SULF1 sulfatase 1
THY1 Thy-1 cell surface antigen
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TNS3 tensin 3
TPD52 tumor protein D52
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABHD2 abhydrolase domain containing 2
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRG6 adhesion G protein-coupled receptor G6
AGR2 anterior gradient 2
AMD1 adenosylmethionine decarboxylase 1
ANGPT1 angiopoietin 1
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AP2M1 adaptor-related protein complex 2, mu 1 subunit
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BASP1 brain abundant, membrane attached signal protein 1
BIRC2 baculoviral IAP repeat containing 2
CD36 CD36 molecule (thrombospondin receptor)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHI3L2 chitinase 3-like 2
CST3 cystatin C
DCLK1 doublecortin-like kinase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FLRT3 fibronectin leucine rich transmembrane protein 3
GPX3 glutathione peroxidase 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
LTBP1 latent transforming growth factor beta binding protein 1
MAGED1 melanoma antigen family D1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NNMT nicotinamide N-methyltransferase
NR2F2 nuclear receptor subfamily 2, group F, member 2
PHACTR2 phosphatase and actin regulator 2
PLK2 polo-like kinase 2
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRL prolactin
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
RBP4 retinol binding protein 4, plasma
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
SACS sacsin molecular chaperone
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SQLE squalene epoxidase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNC tenascin C
UGCG UDP-glucose ceramide glucosyltransferase
WDTC1 WD and tetratricopeptide repeats 1