BRD-K00555438_2-Phenyl-quinoline-4-carboxylic acid [4-(thiazol-2-ylsulfamoyl)-phenyl]-amide MLS-0206672.0001_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

62 genes differentially expressed following the BRD-K00555438_2-Phenyl-quinoline-4-carboxylic acid [4-(thiazol-2-ylsulfamoyl)-phenyl]-amide MLS-0206672.0001_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
CA12 carbonic anhydrase XII
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CDKN2A cyclin-dependent kinase inhibitor 2A
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CSTA cystatin A (stefin A)
CXCL10 chemokine (C-X-C motif) ligand 10
DST dystonin
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLUL glutamate-ammonia ligase
GRIA2 glutamate receptor, ionotropic, AMPA 2
HLX H2.0-like homeobox
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP12 matrix metallopeptidase 12
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NGRN neugrin, neurite outgrowth associated
PTN pleiotrophin
S100A2 S100 calcium binding protein A2
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
TMEM47 transmembrane protein 47
VAV3 vav 3 guanine nucleotide exchange factor

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ALB albumin
APOD apolipoprotein D
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
CRISP3 cysteine-rich secretory protein 3
CXCL14 chemokine (C-X-C motif) ligand 14
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
GLIPR1 GLI pathogenesis-related 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGFBP1 insulin-like growth factor binding protein 1
IRS1 insulin receptor substrate 1
KRT23 keratin 23, type I
KRT8 keratin 8, type II
NT5E 5'-nucleotidase, ecto (CD73)
PDGFC platelet derived growth factor C
PLAT plasminogen activator, tissue
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
RCAN1 regulator of calcineurin 1
S100P S100 calcium binding protein P
SKAP2 src kinase associated phosphoprotein 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
TFF1 trefoil factor 1
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TOB1 transducer of ERBB2, 1