BRD-K00337317_NU-7441_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K00337317_NU-7441_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ALCAM activated leukocyte cell adhesion molecule
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARMCX1 armadillo repeat containing, X-linked 1
ASCL1 achaete-scute family bHLH transcription factor 1
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
CD9 CD9 molecule
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CST6 cystatin E/M
CTSA cathepsin A
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FTH1 ferritin, heavy polypeptide 1
GATA3 GATA binding protein 3
GNPDA1 glucosamine-6-phosphate deaminase 1
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GPX3 glutathione peroxidase 3
GPX4 glutathione peroxidase 4
GRN granulin
HIST1H2BD histone cluster 1, H2bd
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDI1 isopentenyl-diphosphate delta isomerase 1
IRF7 interferon regulatory factor 7
JUP junction plakoglobin
KRT7 keratin 7, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LIMCH1 LIM and calponin homology domains 1
MN1 meningioma (disrupted in balanced translocation) 1
MSMO1 methylsterol monooxygenase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NEU1 sialidase 1 (lysosomal sialidase)
NPC2 Niemann-Pick disease, type C2
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
NUPR1 nuclear protein, transcriptional regulator, 1
PBX1 pre-B-cell leukemia homeobox 1
PDZK1IP1 PDZK1 interacting protein 1
PPL periplakin
RBM47 RNA binding motif protein 47
RHOB ras homolog family member B
S100A7 S100 calcium binding protein A7
SC5D sterol-C5-desaturase
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCPEP1 serine carboxypeptidase 1
SDC4 syndecan 4
SESN1 sestrin 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SQSTM1 sequestosome 1
TTC39A tetratricopeptide repeat domain 39A
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ADRB2 adrenoceptor beta 2, surface
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CKS1B CDC28 protein kinase regulatory subunit 1B
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EHF ets homologous factor
ELANE elastase, neutrophil expressed
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP14 FK506 binding protein 14, 22 kDa
HEPH hephaestin
IGFBP3 insulin-like growth factor binding protein 3
LPL lipoprotein lipase
LTF lactotransferrin
MT1M metallothionein 1M
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PBK PDZ binding kinase
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PSPH phosphoserine phosphatase
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM2 ribonucleotide reductase M2
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNAI2 snail family zinc finger 2
STK10 serine/threonine kinase 10
STK17A serine/threonine kinase 17a
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
THBS1 thrombospondin 1
TNC tenascin C
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSPAN8 tetraspanin 8
ZWILCH zwilch kinetochore protein