BRD-K00313977_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-K00313977_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA5 annexin A5
ASCL1 achaete-scute family bHLH transcription factor 1
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
C3ORF14 chromosome 3 open reading frame 14
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCP110 centriolar coiled coil protein 110kDa
CD163 CD163 molecule
CD52 CD52 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHGB chromogranin B
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLCA4 chloride channel accessory 4
CPD carboxypeptidase D
CPM carboxypeptidase M
CSNK2A2 casein kinase 2, alpha prime polypeptide
DACH1 dachshund family transcription factor 1
DEFB1 defensin, beta 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSE dermatan sulfate epimerase
DUSP6 dual specificity phosphatase 6
EGR2 early growth response 2
EMP1 epithelial membrane protein 1
ESR1 estrogen receptor 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FBP1 fructose-1,6-bisphosphatase 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FZD7 frizzled class receptor 7
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GPX3 glutathione peroxidase 3
GRN granulin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST3H2A histone cluster 3, H2a
HMGN5 high mobility group nucleosome binding domain 5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP5 insulin-like growth factor binding protein 5
INPP1 inositol polyphosphate-1-phosphatase
INSM1 insulinoma-associated 1
INTS6 integrator complex subunit 6
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
OLFM1 olfactomedin 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PBX3 pre-B-cell leukemia homeobox 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLAT plasminogen activator, tissue
RAB13 RAB13, member RAS oncogene family
REEP5 receptor accessory protein 5
RIOK3 RIO kinase 3
RRAGD Ras-related GTP binding D
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB2A2 secretoglobin, family 2A, member 2
SESN1 sestrin 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SSBP2 single-stranded DNA binding protein 2
SYNJ1 synaptojanin 1
TFF3 trefoil factor 3 (intestinal)
TKTL1 transketolase-like 1
TOX3 TOX high mobility group box family member 3
TRIM36 tripartite motif containing 36
TSPAN31 tetraspanin 31
TXNIP thioredoxin interacting protein
UGDH UDP-glucose 6-dehydrogenase
WT1 Wilms tumor 1

decreased expression

Symbol Name
AK2 adenylate kinase 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMDHD2 amidohydrolase domain containing 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASPH aspartate beta-hydroxylase
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AXIN1 axin 1
CDCA4 cell division cycle associated 4
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CHMP6 charged multivesicular body protein 6
CNN3 calponin 3, acidic
COL1A2 collagen, type I, alpha 2
CSRP1 cysteine and glycine-rich protein 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
DCK deoxycytidine kinase
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
FXYD5 FXYD domain containing ion transport regulator 5
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GPX2 glutathione peroxidase 2
H1FX H1 histone family, member X
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA8 heat shock 70kDa protein 8
IFITM3 interferon induced transmembrane protein 3
IFRD2 interferon-related developmental regulator 2
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ITGA6 integrin, alpha 6
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LYZ lysozyme
MCAM melanoma cell adhesion molecule
MSLN mesothelin
MYO10 myosin X
NME4 NME/NM23 nucleoside diphosphate kinase 4
NUP210 nucleoporin 210kDa
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PWP1 PWP1 homolog (S. cerevisiae)
S100A1 S100 calcium binding protein A1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TBCB tubulin folding cofactor B
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
WTAP Wilms tumor 1 associated protein
XPOT exportin, tRNA