BRD-K00088062_Tpl2_SW948_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

55 genes differentially expressed following the BRD-K00088062_Tpl2_SW948_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
COL1A2 collagen, type I, alpha 2
DDIT4 DNA-damage-inducible transcript 4
DOK5 docking protein 5
FAM189A2 family with sequence similarity 189, member A2
FHL1 four and a half LIM domains 1
GAGE3 G antigen 3
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
KDM5D lysine (K)-specific demethylase 5D
LTBP1 latent transforming growth factor beta binding protein 1
MAGEA4 melanoma antigen family A4
MAOB monoamine oxidase B
NELL2 NEL-like 2 (chicken)
PBX3 pre-B-cell leukemia homeobox 3
POSTN periostin, osteoblast specific factor
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SULF1 sulfatase 1
TF transferrin
TMEM30B transmembrane protein 30B
TMSB15A thymosin beta 15a

decreased expression

Symbol Name
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
CAPZB capping protein (actin filament) muscle Z-line, beta
CD320 CD320 molecule
CD59 CD59 molecule, complement regulatory protein
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 chemokine (C-X-C motif) ligand 12
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
FKBP11 FK506 binding protein 11, 19 kDa
GOLM1 golgi membrane protein 1
GRB14 growth factor receptor-bound protein 14
IGKC immunoglobulin kappa constant
LRRC16A leucine rich repeat containing 16A
MAP7 microtubule-associated protein 7
MAPK13 mitogen-activated protein kinase 13
MCOLN1 mucolipin 1
MET MET proto-oncogene, receptor tyrosine kinase
NRIP1 nuclear receptor interacting protein 1
OAT ornithine aminotransferase
PI3 peptidase inhibitor 3, skin-derived
PON2 paraoxonase 2
PPIF peptidylprolyl isomerase F
PRDX2 peroxiredoxin 2
PROM1 prominin 1
RNF167 ring finger protein 167
STK39 serine threonine kinase 39
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
VGLL4 vestigial-like family member 4
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble