BRD-K00088062_Tpl2_NCIH1836_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-K00088062_Tpl2_NCIH1836_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM9 ADAM metallopeptidase domain 9
ANXA1 annexin A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CANX calnexin
CBS cystathionine-beta-synthase
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD24 CD24 molecule
COL11A1 collagen, type XI, alpha 1
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
COL4A1 collagen, type IV, alpha 1
COL5A2 collagen, type V, alpha 2
CTGF connective tissue growth factor
CTSK cathepsin K
CXCL12 chemokine (C-X-C motif) ligand 12
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSP desmoplakin
EGLN3 egl-9 family hypoxia-inducible factor 3
FAM129A family with sequence similarity 129, member A
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLUL glutamate-ammonia ligase
GREM1 gremlin 1, DAN family BMP antagonist
HEBP1 heme binding protein 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
KRT23 keratin 23, type I
MB myoglobin
MFAP3L microfibrillar-associated protein 3-like
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEBL nebulette
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
ORM1 orosomucoid 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFD platelet derived growth factor D
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RND3 Rho family GTPase 3
S100P S100 calcium binding protein P
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SULF1 sulfatase 1
TAGLN transgelin
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNNT1 troponin T type 1 (skeletal, slow)
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
AQP3 aquaporin 3 (Gill blood group)
BST2 bone marrow stromal cell antigen 2
CDC42 cell division cycle 42
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous)
CST3 cystatin C
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GATA2 GATA binding protein 2
GNAS GNAS complex locus
GPX3 glutathione peroxidase 3
GSTP1 glutathione S-transferase pi 1
GTPBP8 GTP-binding protein 8 (putative)
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI30 interferon, gamma-inducible protein 30
KRT5 keratin 5, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMA1 LIM domain and actin binding 1
MACF1 microtubule-actin crosslinking factor 1
MAGED1 melanoma antigen family D1
MAOA monoamine oxidase A
NDN necdin, melanoma antigen (MAGE) family member
NTS neurotensin
PRDX2 peroxiredoxin 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
RPN2 ribophorin II
S100A2 S100 calcium binding protein A2
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SFTPC surfactant protein C
SFTPD surfactant protein D
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPTBN1 spectrin, beta, non-erythrocytic 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIAM1 T-cell lymphoma invasion and metastasis 1
TXNIP thioredoxin interacting protein
UBA1 ubiquitin-like modifier activating enzyme 1
WFDC2 WAP four-disulfide core domain 2