BRD-K00088062_Tpl2_HCC515_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

36 genes differentially expressed following the BRD-K00088062_Tpl2_HCC515_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACTA2 actin, alpha 2, smooth muscle, aorta
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
C3 complement component 3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
GLUL glutamate-ammonia ligase
MSMB microseminoprotein, beta-
MUC1 mucin 1, cell surface associated
MYL9 myosin, light chain 9, regulatory
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PDZK1IP1 PDZK1 interacting protein 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSC22D3 TSC22 domain family, member 3
TSPAN1 tetraspanin 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMIGO2 adhesion molecule with Ig-like domain 2
ARL4C ADP-ribosylation factor-like 4C
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CLC Charcot-Leyden crystal galectin
DUSP6 dual specificity phosphatase 6
EFNB2 ephrin-B2
FOSL1 FOS-like antigen 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H4C histone cluster 1, H4c
IGFBP3 insulin-like growth factor binding protein 3
MMP12 matrix metallopeptidase 12
PFKP phosphofructokinase, platelet
RGS2 regulator of G-protein signaling 2
RND3 Rho family GTPase 3
TKTL1 transketolase-like 1
TLR4 toll-like receptor 4
TRBC1 T cell receptor beta constant 1
ZNF586 zinc finger protein 586