BRD-A95513702_ANDROSTA-1,4-DIEN-3,17-DIONE_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

248 genes differentially expressed following the BRD-A95513702_ANDROSTA-1,4-DIEN-3,17-DIONE_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADIPOR2 adiponectin receptor 2
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CPM carboxypeptidase M
CREB3L1 cAMP responsive element binding protein 3-like 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CYB5R2 cytochrome b5 reductase 2
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DYNLT1 dynein, light chain, Tctex-type 1
ELF1 E74-like factor 1 (ets domain transcription factor)
ELOVL5 ELOVL fatty acid elongase 5
EZR ezrin
FAM134B family with sequence similarity 134, member B
FERMT2 fermitin family member 2
FGL1 fibrinogen-like 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXO1 forkhead box O1
GLRX glutaredoxin (thioltransferase)
GMPR guanosine monophosphate reductase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HGD homogentisate 1,2-dioxygenase
HOMER2 homer scaffolding protein 2
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA2 heat shock 70kDa protein 2
HSPB8 heat shock 22kDa protein 8
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGF1R insulin-like growth factor 1 receptor
INPP1 inositol polyphosphate-1-phosphatase
ISG20 interferon stimulated exonuclease gene 20kDa
KIAA1033 KIAA1033
KIAA1324 KIAA1324
LGMN legumain
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGED1 melanoma antigen family D1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MFAP5 microfibrillar associated protein 5
MICALL1 MICAL-like 1
MLPH melanophilin
MSMB microseminoprotein, beta-
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPY neuropeptide Y
NUCB2 nucleobindin 2
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PER1 period circadian clock 1
PLIN2 perilipin 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
QPCT glutaminyl-peptide cyclotransferase
RAP1GAP RAP1 GTPase activating protein
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100P S100 calcium binding protein P
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SIDT2 SID1 transmembrane family, member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC31A2 solute carrier family 31 (copper transporter), member 2
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SOCS2 suppressor of cytokine signaling 2
SPDEF SAM pointed domain containing ETS transcription factor
STAG3 stromal antigen 3
STAT1 signal transducer and activator of transcription 1, 91kDa
STK10 serine/threonine kinase 10
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCTA T-cell leukemia translocation altered
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
UBXN4 UBX domain protein 4
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP6NL USP6 N-terminal like
VCL vinculin
WIPI1 WD repeat domain, phosphoinositide interacting 1
XAF1 XIAP associated factor 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANKRD10 ankyrin repeat domain 10
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASS1 argininosuccinate synthase 1
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BZW2 basic leucine zipper and W2 domains 2
CA2 carbonic anhydrase II
CACYBP calcyclin binding protein
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCDC85B coiled-coil domain containing 85B
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CHEK2 checkpoint kinase 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTPS1 CTP synthase 1
CTSC cathepsin C
CXADR coxsackie virus and adenovirus receptor
CXCL14 chemokine (C-X-C motif) ligand 14
DCK deoxycytidine kinase
DIAPH2 diaphanous-related formin 2
DKC1 dyskeratosis congenita 1, dyskerin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF4A3 eukaryotic translation initiation factor 4A3
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPN2 epsin 2
EPS8 epidermal growth factor receptor pathway substrate 8
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EXOSC5 exosome component 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FBL fibrillarin
FBLN1 fibulin 1
FERMT1 fermitin family member 1
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
HELLS helicase, lymphoid-specific
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOPX HOP homeobox
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL17RB interleukin 17 receptor B
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
LAMP5 lysosomal-associated membrane protein family, member 5
LEF1 lymphoid enhancer-binding factor 1
LIG1 ligase I, DNA, ATP-dependent
LOXL1 lysyl oxidase-like 1
MCM10 minichromosome maintenance complex component 10
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MRPS2 mitochondrial ribosomal protein S2
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAPH non-SMC condensin I complex, subunit H
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NMU neuromedin U
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOV nephroblastoma overexpressed
NT5DC2 5'-nucleotidase domain containing 2
NUSAP1 nucleolar and spindle associated protein 1
ORC6 origin recognition complex, subunit 6
OXCT1 3-oxoacid CoA transferase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PMP22 peripheral myelin protein 22
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
PRC1 protein regulator of cytokinesis 1
PRDX2 peroxiredoxin 2
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PSPH phosphoserine phosphatase
PUS7 pseudouridylate synthase 7 (putative)
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RNASEH2A ribonuclease H2, subunit A
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPA2 replication protein A2, 32kDa
RPL22 ribosomal protein L22
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSL1D1 ribosomal L1 domain containing 1
SNX10 sorting nexin 10
SPC25 SPC25, NDC80 kinetochore complex component
SRSF7 serine/arginine-rich splicing factor 7
ST7 suppression of tumorigenicity 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TARBP1 TAR (HIV-1) RNA binding protein 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TPX2 TPX2, microtubule-associated
TRIB1 tribbles pseudokinase 1
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
TUBB tubulin, beta class I
UBE2C ubiquitin-conjugating enzyme E2C
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WNT5A wingless-type MMTV integration site family, member 5A
YBX3 Y box binding protein 3