BRD-A95445494_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-A95445494_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
CAST calpastatin
CCL2 chemokine (C-C motif) ligand 2
CD52 CD52 molecule
CD59 CD59 molecule, complement regulatory protein
CHMP4A charged multivesicular body protein 4A
CKB creatine kinase, brain
CNN3 calponin 3, acidic
COL1A2 collagen, type I, alpha 2
COL6A2 collagen, type VI, alpha 2
DCN decorin
EML3 echinoderm microtubule associated protein like 3
FGR FGR proto-oncogene, Src family tyrosine kinase
HOXA5 homeobox A5
HOXB2 homeobox B2
HOXB6 homeobox B6
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLK5 kallikrein-related peptidase 5
LAPTM4B lysosomal protein transmembrane 4 beta
LTF lactotransferrin
MCOLN1 mucolipin 1
MLPH melanophilin
NEFH neurofilament, heavy polypeptide
NNT nicotinamide nucleotide transhydrogenase
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PRF1 perforin 1 (pore forming protein)
REC8 REC8 meiotic recombination protein
RHOA ras homolog family member A
S100A10 S100 calcium binding protein A10
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC16A6 solute carrier family 16, member 6
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TAGLN2 transgelin 2
TKTL1 transketolase-like 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52 tumor protein D52
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ALCAM activated leukocyte cell adhesion molecule
AREG amphiregulin
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AXL AXL receptor tyrosine kinase
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
BLNK B-cell linker
CCND1 cyclin D1
CD93 CD93 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CIAPIN1 cytokine induced apoptosis inhibitor 1
CLU clusterin
CTGF connective tissue growth factor
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DKK3 dickkopf WNT signaling pathway inhibitor 3
ESR1 estrogen receptor 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM107A family with sequence similarity 107, member A
FERMT2 fermitin family member 2
FKSG49 FKSG49
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INSR insulin receptor
KIF5C kinesin family member 5C
KLF4 Kruppel-like factor 4 (gut)
LAMP5 lysosomal-associated membrane protein family, member 5
LMO2 LIM domain only 2 (rhombotin-like 1)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LXN latexin
MAGT1 magnesium transporter 1
MEF2C myocyte enhancer factor 2C
MYH11 myosin, heavy chain 11, smooth muscle
MZT2B mitotic spindle organizing protein 2B
NEBL nebulette
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PEBP1 phosphatidylethanolamine binding protein 1
PODXL podocalyxin-like
RGS5 regulator of G-protein signaling 5
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STC1 stanniocalcin 1
STOM stomatin
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCF4 transcription factor 4
TFF1 trefoil factor 1
TMEM47 transmembrane protein 47
TXN thioredoxin
VDAC1 voltage-dependent anion channel 1
WFDC1 WAP four-disulfide core domain 1
ZNF721 zinc finger protein 721
ZW10 zw10 kinetochore protein