BRD-A94756469_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

161 genes differentially expressed following the BRD-A94756469_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ANKRD11 ankyrin repeat domain 11
ANKRD28 ankyrin repeat domain 28
ATF1 activating transcription factor 1
ATF3 activating transcription factor 3
ATG12 autophagy related 12
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATRX alpha thalassemia/mental retardation syndrome X-linked
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BBX bobby sox homolog (Drosophila)
BIRC2 baculoviral IAP repeat containing 2
BTG3 BTG family, member 3
CD9 CD9 molecule
CDK17 cyclin-dependent kinase 17
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHIC2 cysteine-rich hydrophobic domain 2
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
CRABP1 cellular retinoic acid binding protein 1
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DMTF1 cyclin D binding myb-like transcription factor 1
DNM3 dynamin 3
DNMBP dynamin binding protein
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
ELF1 E74-like factor 1 (ets domain transcription factor)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FZD6 frizzled class receptor 6
FZD7 frizzled class receptor 7
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HIST1H4C histone cluster 1, H4c
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
INHBA inhibin, beta A
JUN jun proto-oncogene
KIAA0226L KIAA0226-like
LEPROT leptin receptor overlapping transcript
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL1 muscleblind-like splicing regulator 1
MEIS2 Meis homeobox 2
MPPED2 metallophosphoesterase domain containing 2
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT1E metallothionein 1E
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFE2L2 nuclear factor, erythroid 2-like 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPL1 nucleoporin like 1
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PHACTR2 phosphatase and actin regulator 2
PLAT plasminogen activator, tissue
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNISR PNN-interacting serine/arginine-rich protein
PROM1 prominin 1
PRRC2C proline-rich coiled-coil 2C
PTBP2 polypyrimidine tract binding protein 2
RGS1 regulator of G-protein signaling 1
RYBP RING1 and YY1 binding protein
SAT1 spermidine/spermine N1-acetyltransferase 1
SERTAD2 SERTA domain containing 2
SFRP1 secreted frizzled-related protein 1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SON SON DNA binding protein
SOX9 SRY (sex determining region Y)-box 9
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SYNJ2 synaptojanin 2
TANK TRAF family member-associated NFKB activator
TCF4 transcription factor 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC22D2 TSC22 domain family, member 2
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
UFM1 ubiquitin-fold modifier 1
VIM vimentin
WIPF1 WAS/WASL interacting protein family, member 1
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
ZBTB10 zinc finger and BTB domain containing 10

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
AIM1 absent in melanoma 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA6 annexin A6
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
C1ORF116 chromosome 1 open reading frame 116
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CES1 carboxylesterase 1
CSRP1 cysteine and glycine-rich protein 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB5A cytochrome b5 type A (microsomal)
DCN decorin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5 eukaryotic translation initiation factor 5
FXYD6 FXYD domain containing ion transport regulator 6
FYN FYN proto-oncogene, Src family tyrosine kinase
GPX3 glutathione peroxidase 3
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KEAP1 kelch-like ECH-associated protein 1
KIF20A kinesin family member 20A
MAT2A methionine adenosyltransferase II, alpha
MSH6 mutS homolog 6
MYH11 myosin, heavy chain 11, smooth muscle
NELL2 NEL-like 2 (chicken)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPY1R neuropeptide Y receptor Y1
PKM pyruvate kinase, muscle
PRR7 proline rich 7 (synaptic)
PRUNE2 prune homolog 2 (Drosophila)
RPS11 ribosomal protein S11
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SET SET nuclear proto-oncogene
SOX4 SRY (sex determining region Y)-box 4
STEAP3 STEAP family member 3, metalloreductase
TMEM100 transmembrane protein 100
TPM1 tropomyosin 1 (alpha)
TRIM16 tripartite motif containing 16
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
XBP1 X-box binding protein 1
ZW10 zw10 kinetochore protein