BRD-A94413429_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-A94413429_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACAT2 acetyl-CoA acetyltransferase 2
ACSL3 acyl-CoA synthetase long-chain family member 3
AREG amphiregulin
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ASS1 argininosuccinate synthase 1
C14ORF1 chromosome 14 open reading frame 1
CD99 CD99 molecule
CHMP4A charged multivesicular body protein 4A
CPT1A carnitine palmitoyltransferase 1A (liver)
CTSK cathepsin K
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
EBP emopamil binding protein (sterol isomerase)
EIF5A eukaryotic translation initiation factor 5A
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FTH1 ferritin, heavy polypeptide 1
GAS1 growth arrest-specific 1
GNAS GNAS complex locus
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAN1A1 mannosidase, alpha, class 1A, member 1
MFAP5 microfibrillar associated protein 5
MSMO1 methylsterol monooxygenase 1
MYO1D myosin ID
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NID2 nidogen 2 (osteonidogen)
OPN3 opsin 3
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDZD2 PDZ domain containing 2
REEP1 receptor accessory protein 1
RGS1 regulator of G-protein signaling 1
S100A14 S100 calcium binding protein A14
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SQLE squalene epoxidase
SQSTM1 sequestosome 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TMEM97 transmembrane protein 97
WBP5 WW domain binding protein 5

decreased expression

Symbol Name
AIM2 absent in melanoma 2
ANXA10 annexin A10
AUTS2 autism susceptibility candidate 2
BASP1 brain abundant, membrane attached signal protein 1
CNPY3 canopy FGF signaling regulator 3
CST7 cystatin F (leukocystatin)
CTSG cathepsin G
ELANE elastase, neutrophil expressed
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
IL7R interleukin 7 receptor
KCTD12 potassium channel tetramerization domain containing 12
MET MET proto-oncogene, receptor tyrosine kinase
MFSD10 major facilitator superfamily domain containing 10
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NAV3 neuron navigator 3
P3H2 prolyl 3-hydroxylase 2
PLBD1 phospholipase B domain containing 1
PRTN3 proteinase 3
RCAN1 regulator of calcineurin 1
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNASE3 ribonuclease, RNase A family, 3
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
SLPI secretory leukocyte peptidase inhibitor
SPRY2 sprouty homolog 2 (Drosophila)
TLR4 toll-like receptor 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
ZBTB18 zinc finger and BTB domain containing 18