BRD-A89067742_HTS 10765_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-A89067742_HTS 10765_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
AK2 adenylate kinase 2
ANGPTL2 angiopoietin-like 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BIRC3 baculoviral IAP repeat containing 3
C8ORF4 chromosome 8 open reading frame 4
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CCDC85B coiled-coil domain containing 85B
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CHERP calcium homeostasis endoplasmic reticulum protein
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPT dermatopontin
ESR1 estrogen receptor 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2RL1 coagulation factor II (thrombin) receptor-like 1
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GPM6B glycoprotein M6B
GSTM3 glutathione S-transferase mu 3 (brain)
GUSBP11 glucuronidase, beta pseudogene 11
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI44 interferon-induced protein 44
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IL1RN interleukin 1 receptor antagonist
IL32 interleukin 32
KIF2C kinesin family member 2C
KLF6 Kruppel-like factor 6
LIG1 ligase I, DNA, ATP-dependent
LTF lactotransferrin
MED13L mediator complex subunit 13-like
MEX3D mex-3 RNA binding family member D
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NBPF10 neuroblastoma breakpoint family, member 10
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKG7 natural killer cell granule protein 7
OLFML2A olfactomedin-like 2A
PARP2 poly (ADP-ribose) polymerase 2
PAXBP1 PAX3 and PAX7 binding protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PILRB paired immunoglobin-like type 2 receptor beta
PNN pinin, desmosome associated protein
PRPF4 pre-mRNA processing factor 4
RASIP1 Ras interacting protein 1
RBM6 RNA binding motif protein 6
RBMS1 RNA binding motif, single stranded interacting protein 1
RBP1 retinol binding protein 1, cellular
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPL10 ribosomal protein L10
SCO2 SCO2 cytochrome c oxidase assembly protein
SFRP4 secreted frizzled-related protein 4
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SST somatostatin
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TESC tescalcin
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNPO1 transportin 1
TSTA3 tissue specific transplantation antigen P35B
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACPP acid phosphatase, prostate
ACSL3 acyl-CoA synthetase long-chain family member 3
ACTG2 actin, gamma 2, smooth muscle, enteric
AIM1 absent in melanoma 1
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
BASP1 brain abundant, membrane attached signal protein 1
BCL2L13 BCL2-like 13 (apoptosis facilitator)
CCNB2 cyclin B2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK19 cyclin-dependent kinase 19
CFD complement factor D (adipsin)
CFH complement factor H
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
CREBL2 cAMP responsive element binding protein-like 2
CSRP1 cysteine and glycine-rich protein 1
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DHCR24 24-dehydrocholesterol reductase
EID1 EP300 interacting inhibitor of differentiation 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXA1 forkhead box A1
FXYD3 FXYD domain containing ion transport regulator 3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GSTT1 glutathione S-transferase theta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXB13 homeobox B13
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IGFBP1 insulin-like growth factor binding protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INSIG1 insulin induced gene 1
KDM5D lysine (K)-specific demethylase 5D
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
LDLR low density lipoprotein receptor
LEPROT leptin receptor overlapping transcript
LRP10 low density lipoprotein receptor-related protein 10
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MRPL40 mitochondrial ribosomal protein L40
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MSMO1 methylsterol monooxygenase 1
MUT methylmalonyl CoA mutase
MYH11 myosin, heavy chain 11, smooth muscle
NEK7 NIMA-related kinase 7
NPY neuropeptide Y
ORAI3 ORAI calcium release-activated calcium modulator 3
PCCA propionyl CoA carboxylase, alpha polypeptide
PCCB propionyl CoA carboxylase, beta polypeptide
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDLIM5 PDZ and LIM domain 5
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PSIP1 PC4 and SFRS1 interacting protein 1
RAP1GAP RAP1 GTPase activating protein
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RGS10 regulator of G-protein signaling 10
SC5D sterol-C5-desaturase
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMS spermine synthase
SNAP29 synaptosomal-associated protein, 29kDa
SPDEF SAM pointed domain containing ETS transcription factor
SQLE squalene epoxidase
TCTA T-cell leukemia translocation altered
TM7SF2 transmembrane 7 superfamily member 2
TMSB15A thymosin beta 15a
TSPAN4 tetraspanin 4
TUBA1A tubulin, alpha 1a
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X