BRD-A87137733_GSK-690693_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-A87137733_GSK-690693_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
ANXA3 annexin A3
ARHGAP29 Rho GTPase activating protein 29
BACE2 beta-site APP-cleaving enzyme 2
BICC1 BicC family RNA binding protein 1
C10ORF10 chromosome 10 open reading frame 10
CANX calnexin
CAV2 caveolin 2
CLEC2B C-type lectin domain family 2, member B
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCN decorin
DOCK9 dedicator of cytokinesis 9
DRAM1 DNA-damage regulated autophagy modulator 1
DSP desmoplakin
DUSP10 dual specificity phosphatase 10
DYNLT3 dynein, light chain, Tctex-type 3
EDN1 endothelin 1
EGFR epidermal growth factor receptor
ERBB3 erb-b2 receptor tyrosine kinase 3
FERMT2 fermitin family member 2
FLRT2 fibronectin leucine rich transmembrane protein 2
GADD45B growth arrest and DNA-damage-inducible, beta
GNB5 guanine nucleotide binding protein (G protein), beta 5
GREM1 gremlin 1, DAN family BMP antagonist
HPSE heparanase
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IGFBP7 insulin-like growth factor binding protein 7
IRF9 interferon regulatory factor 9
JUP junction plakoglobin
KCTD12 potassium channel tetramerization domain containing 12
KLK10 kallikrein-related peptidase 10
KRT7 keratin 7, type II
LEPR leptin receptor
LEPROT leptin receptor overlapping transcript
LGALS8 lectin, galactoside-binding, soluble, 8
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEIS2 Meis homeobox 2
MGLL monoglyceride lipase
MSN moesin
MT2A metallothionein 2A
MVP major vault protein
MX1 MX dynamin-like GTPase 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OPTN optineurin
PAM peptidylglycine alpha-amidating monooxygenase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PAWR PRKC, apoptosis, WT1, regulator
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLSCR4 phospholipid scramblase 4
PRSS23 protease, serine, 23
RFTN1 raftlin, lipid raft linker 1
RND3 Rho family GTPase 3
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SAMD4A sterile alpha motif domain containing 4A
SC5D sterol-C5-desaturase
SKAP2 src kinase associated phosphoprotein 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SOX4 SRY (sex determining region Y)-box 4
SRPX sushi-repeat containing protein, X-linked
SST somatostatin
TM4SF1 transmembrane 4 L six family member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM22 tripartite motif containing 22
TSPAN4 tetraspanin 4
VIM vimentin
WWTR1 WW domain containing transcription regulator 1
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
AQP3 aquaporin 3 (Gill blood group)
BID BH3 interacting domain death agonist
CALML4 calmodulin-like 4
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CHEK2 checkpoint kinase 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPD carboxypeptidase D
CTSC cathepsin C
CXCR4 chemokine (C-X-C motif) receptor 4
DUOX2 dual oxidase 2
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GPX2 glutathione peroxidase 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYZ lysozyme
MAP2K6 mitogen-activated protein kinase kinase 6
MMP12 matrix metallopeptidase 12
PIGR polymeric immunoglobulin receptor
PLBD1 phospholipase B domain containing 1
POSTN periostin, osteoblast specific factor
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SORD sorbitol dehydrogenase
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase