BRD-A85860691_chaetocin_A375_24.0_h_0.08_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

389 genes differentially expressed following the BRD-A85860691_chaetocin_A375_24.0_h_0.08_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANKRD10 ankyrin repeat domain 10
ANKRD12 ankyrin repeat domain 12
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC3 baculoviral IAP repeat containing 3
BLNK B-cell linker
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
C21ORF91 chromosome 21 open reading frame 91
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CARKD carbohydrate kinase domain containing
CCL20 chemokine (C-C motif) ligand 20
CCL8 chemokine (C-C motif) ligand 8
CD38 CD38 molecule
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHMP1B charged multivesicular body protein 1B
CHMP5 charged multivesicular body protein 5
CLEC2B C-type lectin domain family 2, member B
CLEC5A C-type lectin domain family 5, member A
CLGN calmegin
CRABP2 cellular retinoic acid binding protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CYR61 cysteine-rich, angiogenic inducer, 61
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
DENND1A DENN/MADD domain containing 1A
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FHL2 four and a half LIM domains 2
FOSL2 FOS-like antigen 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAS6 growth arrest-specific 6
GEM GTP binding protein overexpressed in skeletal muscle
GLA galactosidase, alpha
GOLT1B golgi transport 1B
GPNMB glycoprotein (transmembrane) nmb
GSE1 Gse1 coiled-coil protein
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HPSE heparanase
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER5 immediate early response 5
ISG20 interferon stimulated exonuclease gene 20kDa
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KIAA0226L KIAA0226-like
KLHDC10 kelch domain containing 10
KLHL24 kelch-like family member 24
KLK10 kallikrein-related peptidase 10
LAMP3 lysosomal-associated membrane protein 3
LGALS4 lectin, galactoside-binding, soluble, 4
LIMK2 LIM domain kinase 2
LMO3 LIM domain only 3 (rhombotin-like 2)
LSG1 large 60S subunit nuclear export GTPase 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCTP1 multiple C2 domains, transmembrane 1
MDK midkine (neurite growth-promoting factor 2)
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MSLN mesothelin
NCF2 neutrophil cytosolic factor 2
NELL2 NEL-like 2 (chicken)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUPR1 nuclear protein, transcriptional regulator, 1
ODC1 ornithine decarboxylase 1
ORM1 orosomucoid 1
OSER1 oxidative stress responsive serine-rich 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PDGFA platelet-derived growth factor alpha polypeptide
PEG3 paternally expressed 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PON3 paraoxonase 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRPF3 pre-mRNA processing factor 3
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PYCARD PYD and CARD domain containing
RAB32 RAB32, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBKS ribokinase
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS16 regulator of G-protein signaling 16
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNMT RNA (guanine-7-) methyltransferase
RSAD2 radical S-adenosyl methionine domain containing 2
RSL1D1 ribosomal L1 domain containing 1
RSRC2 arginine/serine-rich coiled-coil 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SEH1L SEH1-like (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP4 secreted frizzled-related protein 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SOCS1 suppressor of cytokine signaling 1
SOD2 superoxide dismutase 2, mitochondrial
SQLE squalene epoxidase
SS18 synovial sarcoma translocation, chromosome 18
STK26 serine/threonine protein kinase 26
STX4 syntaxin 4
TDO2 tryptophan 2,3-dioxygenase
TM4SF4 transmembrane 4 L six family member 4
TMPRSS3 transmembrane protease, serine 3
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TPM4 tropomyosin 4
TRIB3 tribbles pseudokinase 3
TYMP thymidine phosphorylase
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
WTAP Wilms tumor 1 associated protein
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331
ZNF423 zinc finger protein 423

decreased expression

Symbol Name
AASS aminoadipate-semialdehyde synthase
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
ABHD2 abhydrolase domain containing 2
ABLIM3 actin binding LIM protein family, member 3
ACSL3 acyl-CoA synthetase long-chain family member 3
ADD3 adducin 3 (gamma)
ADGRG6 adhesion G protein-coupled receptor G6
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKAP7 A kinase (PRKA) anchor protein 7
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDOC aldolase C, fructose-bisphosphate
AMACR alpha-methylacyl-CoA racemase
AMD1 adenosylmethionine decarboxylase 1
ANXA7 annexin A7
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APOD apolipoprotein D
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
BACE2 beta-site APP-cleaving enzyme 2
BASP1 brain abundant, membrane attached signal protein 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTBD3 BTB (POZ) domain containing 3
BTN3A2 butyrophilin, subfamily 3, member A2
C1QTNF3 C1q and tumor necrosis factor related protein 3
C3 complement component 3
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CAST calpastatin
CAV2 caveolin 2
CCND1 cyclin D1
CCNG1 cyclin G1
CD44 CD44 molecule (Indian blood group)
CD59 CD59 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD81 CD81 molecule
CD99 CD99 molecule
CDH19 cadherin 19, type 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHPT1 choline phosphotransferase 1
CLSTN1 calsyntenin 1
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COG2 component of oligomeric golgi complex 2
COL1A2 collagen, type I, alpha 2
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CPOX coproporphyrinogen oxidase
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTSC cathepsin C
CXCL14 chemokine (C-X-C motif) ligand 14
CYTL1 cytokine-like 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT4 DNA-damage-inducible transcript 4
DNM1 dynamin 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DPY19L1 dpy-19-like 1 (C. elegans)
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
ECI2 enoyl-CoA delta isomerase 2
ECM1 extracellular matrix protein 1
EDNRB endothelin receptor type B
EHD3 EH-domain containing 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENO2 enolase 2 (gamma, neuronal)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERLIN2 ER lipid raft associated 2
F2R coagulation factor II (thrombin) receptor
FAM134B family with sequence similarity 134, member B
FBLN5 fibulin 5
FBN1 fibrillin 1
FERMT1 fermitin family member 1
FGF13 fibroblast growth factor 13
FHL1 four and a half LIM domains 1
FSTL1 follistatin-like 1
FXYD3 FXYD domain containing ion transport regulator 3
FXYD5 FXYD domain containing ion transport regulator 5
G6PC3 glucose 6 phosphatase, catalytic, 3
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GLB1 galactosidase, beta 1
GLRX5 glutaredoxin 5
GNAS GNAS complex locus
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPM6B glycoprotein M6B
GSN gelsolin
HEG1 heart development protein with EGF-like domains 1
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLTF helicase-like transcription factor
HMG20B high mobility group 20B
HMGA2 high mobility group AT-hook 2
HSPB8 heat shock 22kDa protein 8
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
INPP5F inositol polyphosphate-5-phosphatase F
ITGB5 integrin, beta 5
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
KANK2 KN motif and ankyrin repeat domains 2
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0232 KIAA0232
KRT18 keratin 18, type I
L1CAM L1 cell adhesion molecule
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LASP1 LIM and SH3 protein 1
LBR lamin B receptor
LEPR leptin receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMO2 LIM domain only 2 (rhombotin-like 1)
LOXL2 lysyl oxidase-like 2
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRP4 low density lipoprotein receptor-related protein 4
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MAPT microtubule-associated protein tau
MARCKSL1 MARCKS-like 1
MEGF9 multiple EGF-like-domains 9
MGP matrix Gla protein
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MOK MOK protein kinase
MPZL1 myelin protein zero-like 1
MYH10 myosin, heavy chain 10, non-muscle
NBL1 neuroblastoma 1, DAN family BMP antagonist
NDN necdin, melanoma antigen (MAGE) family member
NDRG3 NDRG family member 3
NES nestin
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOTCH2 notch 2
NPY neuropeptide Y
NRP1 neuropilin 1
OSBPL8 oxysterol binding protein-like 8
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PARP4 poly (ADP-ribose) polymerase family, member 4
PDLIM2 PDZ and LIM domain 2 (mystique)
PEBP1 phosphatidylethanolamine binding protein 1
PGM1 phosphoglucomutase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLAT plasminogen activator, tissue
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLLP plasmolipin
PLP1 proteolipid protein 1
PMEPA1 prostate transmembrane protein, androgen induced 1
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PROM1 prominin 1
PRSS23 protease, serine, 23
PSIP1 PC4 and SFRS1 interacting protein 1
PTCH1 patched 1
PURA purine-rich element binding protein A
PYGB phosphorylase, glycogen; brain
QDPR quinoid dihydropteridine reductase
QPCT glutaminyl-peptide cyclotransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RBPMS RNA binding protein with multiple splicing
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
REEP5 receptor accessory protein 5
RHOBTB3 Rho-related BTB domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A11 S100 calcium binding protein A11
S100A6 S100 calcium binding protein A6
S100B S100 calcium binding protein B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCP2 sterol carrier protein 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEPT11 septin 11
SEPT8 septin 8
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SET SET nuclear proto-oncogene
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMS spermine synthase
SORBS3 sorbin and SH3 domain containing 3
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX10 SRY (sex determining region Y)-box 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRPX sushi-repeat containing protein, X-linked
STK32B serine/threonine kinase 32B
STOM stomatin
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TACC1 transforming, acidic coiled-coil containing protein 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIMP4 TIMP metallopeptidase inhibitor 4
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM2 transmembrane protein 2
TMEM50A transmembrane protein 50A
TMX1 thioredoxin-related transmembrane protein 1
TNS3 tensin 3
TPM1 tropomyosin 1 (alpha)
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
VCAN versican
VCL vinculin
WDR1 WD repeat domain 1
WIPF1 WAS/WASL interacting protein family, member 1
WWTR1 WW domain containing transcription regulator 1
XPO7 exportin 7
ZCCHC24 zinc finger, CCHC domain containing 24
ZMYND8 zinc finger, MYND-type containing 8
ZNF512B zinc finger protein 512B