BRD-A84524947_1-(3,4-bis(benzyloxy)-2,5-difluorophenyl)-2-(methylamino)ethanol KLK-37_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-A84524947_1-(3,4-bis(benzyloxy)-2,5-difluorophenyl)-2-(methylamino)ethanol KLK-37_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACLY ATP citrate lyase
ALCAM activated leukocyte cell adhesion molecule
AREG amphiregulin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE40 basic helix-loop-helix family, member e40
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELOVL5 ELOVL fatty acid elongase 5
EMP1 epithelial membrane protein 1
EZR ezrin
FADS1 fatty acid desaturase 1
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
G6PD glucose-6-phosphate dehydrogenase
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
IQGAP1 IQ motif containing GTPase activating protein 1
KTN1 kinectin 1 (kinesin receptor)
LDLR low density lipoprotein receptor
LEF1 lymphoid enhancer-binding factor 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MSMO1 methylsterol monooxygenase 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
PIP prolactin-induced protein
PNKP polynucleotide kinase 3'-phosphatase
PRAME preferentially expressed antigen in melanoma
RRAGD Ras-related GTP binding D
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFRP4 secreted frizzled-related protein 4
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A1 solute carrier family 38, member 1
SQLE squalene epoxidase
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
TKT transketolase
TPSAB1 tryptase alpha/beta 1
TRIM16 tripartite motif containing 16
TRIM2 tripartite motif containing 2

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ANXA1 annexin A1
AQP1 aquaporin 1 (Colton blood group)
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CPE carboxypeptidase E
CRYAB crystallin, alpha B
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOXC1 forkhead box C1
GREM1 gremlin 1, DAN family BMP antagonist
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ISG15 ISG15 ubiquitin-like modifier
KAT6B K(lysine) acetyltransferase 6B
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MGLL monoglyceride lipase
MT1E metallothionein 1E
MT1M metallothionein 1M
PLAC8 placenta-specific 8
POSTN periostin, osteoblast specific factor
PROM1 prominin 1
SCG5 secretogranin V
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
TCTA T-cell leukemia translocation altered
TMEM176B transmembrane protein 176B
TRAPPC4 trafficking protein particle complex 4
TXNDC9 thioredoxin domain containing 9
YME1L1 YME1-like 1 ATPase