BRD-A79768653_sirolimus_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

123 genes differentially expressed following the BRD-A79768653_sirolimus_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADA adenosine deaminase
ALCAM activated leukocyte cell adhesion molecule
AMOTL2 angiomotin like 2
AREG amphiregulin
ARID5B AT rich interactive domain 5B (MRF1-like)
ASS1 argininosuccinate synthase 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BEX4 brain expressed, X-linked 4
BIRC3 baculoviral IAP repeat containing 3
C1ORF115 chromosome 1 open reading frame 115
CALCRL calcitonin receptor-like
CCR7 chemokine (C-C motif) receptor 7
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
COL11A1 collagen, type XI, alpha 1
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CTSH cathepsin H
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
FGFR2 fibroblast growth factor receptor 2
FN1 fibronectin 1
FOXO1 forkhead box O1
GPC4 glypican 4
HLA-E major histocompatibility complex, class I, E
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
INSR insulin receptor
IRS2 insulin receptor substrate 2
ITGAV integrin, alpha V
JAG1 jagged 1
LBH limb bud and heart development
LCN2 lipocalin 2
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MYB v-myb avian myeloblastosis viral oncogene homolog
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NNMT nicotinamide N-methyltransferase
NPY neuropeptide Y
NTS neurotensin
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PLA1A phospholipase A1 member A
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PROM1 prominin 1
RAB13 RAB13, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCN1 reticulocalbin 1, EF-hand calcium binding domain
S100A8 S100 calcium binding protein A8
SELL selectin L
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SOX4 SRY (sex determining region Y)-box 4
SULF1 sulfatase 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS1 thrombospondin 1
TM7SF2 transmembrane 7 superfamily member 2
VCAN versican
VNN1 vanin 1

decreased expression

Symbol Name
AK4 adenylate kinase 4
ARL4C ADP-ribosylation factor-like 4C
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
AURKB aurora kinase B
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CAST calpastatin
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CENPU centromere protein U
CFH complement factor H
CSE1L CSE1 chromosome segregation 1-like (yeast)
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM162A family with sequence similarity 162, member A
FEN1 flap structure-specific endonuclease 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPI glucose-6-phosphate isomerase
HK2 hexokinase 2
IQGAP2 IQ motif containing GTPase activating protein 2
KRT19 keratin 19, type I
LAMA3 laminin, alpha 3
LAP3 leucine aminopeptidase 3
LIG1 ligase I, DNA, ATP-dependent
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
METTL7A methyltransferase like 7A
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NET1 neuroepithelial cell transforming 1
PCNA proliferating cell nuclear antigen
PCSK1 proprotein convertase subtilisin/kexin type 1
PFKP phosphofructokinase, platelet
PHLDA1 pleckstrin homology-like domain, family A, member 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RFC2 replication factor C (activator 1) 2, 40kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SDC1 syndecan 1
SHCBP1 SHC SH2-domain binding protein 1
SOX10 SRY (sex determining region Y)-box 10
SPP1 secreted phosphoprotein 1
SRGN serglycin
TMEM97 transmembrane protein 97
VEGFA vascular endothelial growth factor A