BRD-A77467113_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-A77467113_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ATF3 activating transcription factor 3
AXL AXL receptor tyrosine kinase
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CLDN10 claudin 10
COTL1 coactosin-like F-actin binding protein 1
CSRP1 cysteine and glycine-rich protein 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
GULP1 GULP, engulfment adaptor PTB domain containing 1
HCAR3 hydroxycarboxylic acid receptor 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KYNU kynureninase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MT2A metallothionein 2A
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
PDLIM5 PDZ and LIM domain 5
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTX3 pentraxin 3, long
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SERTAD2 SERTA domain containing 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
CALB1 calbindin 1, 28kDa
CALU calumenin
CCND2 cyclin D2
COL1A2 collagen, type I, alpha 2
COL6A3 collagen, type VI, alpha 3
DUOX2 dual oxidase 2
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FAM49A family with sequence similarity 49, member A
FHL1 four and a half LIM domains 1
FRZB frizzled-related protein
G0S2 G0/G1 switch 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
KIAA0907 KIAA0907
LRRC17 leucine rich repeat containing 17
MAN1A1 mannosidase, alpha, class 1A, member 1
MFAP4 microfibrillar-associated protein 4
MLEC malectin
NPY1R neuropeptide Y receptor Y1
PCP4 Purkinje cell protein 4
PDZRN3 PDZ domain containing ring finger 3
PLN phospholamban
RCN2 reticulocalbin 2, EF-hand calcium binding domain
REG1A regenerating islet-derived 1 alpha
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
TFPI2 tissue factor pathway inhibitor 2
TMEM50B transmembrane protein 50B
TPPP3 tubulin polymerization-promoting protein family member 3
WRB tryptophan rich basic protein