BRD-A76528577_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-A76528577_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
ARG2 arginase 2
BID BH3 interacting domain death agonist
BIK BCL2-interacting killer (apoptosis-inducing)
BRD4 bromodomain containing 4
CD9 CD9 molecule
CHIC2 cysteine-rich hydrophobic domain 2
CLC Charcot-Leyden crystal galectin
COL1A1 collagen, type I, alpha 1
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EPAS1 endothelial PAS domain protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GBP1 guanylate binding protein 1, interferon-inducible
GSN gelsolin
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL7R interleukin 7 receptor
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMP3 lysosomal-associated membrane protein 3
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MICALL1 MICAL-like 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1G metallothionein 1G
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PALLD palladin, cytoskeletal associated protein
PEA15 phosphoprotein enriched in astrocytes 15
RGCC regulator of cell cycle
RHOB ras homolog family member B
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SELE selectin E
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SHB Src homology 2 domain containing adaptor protein B
SOX4 SRY (sex determining region Y)-box 4
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TUBA1A tubulin, alpha 1a
TXNDC9 thioredoxin domain containing 9
WSB2 WD repeat and SOCS box containing 2

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADAM10 ADAM metallopeptidase domain 10
ADGRG2 adhesion G protein-coupled receptor G2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
BAMBI BMP and activin membrane-bound inhibitor
C1S complement component 1, s subcomponent
CCND2 cyclin D2
CDC20 cell division cycle 20
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CXCL12 chemokine (C-X-C motif) ligand 12
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
FGFR3 fibroblast growth factor receptor 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPER1 G protein-coupled estrogen receptor 1
HBB hemoglobin, beta
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFITM2 interferon induced transmembrane protein 2
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITM2A integral membrane protein 2A
KANK2 KN motif and ankyrin repeat domains 2
KIAA0485 uncharacterized LOC57235
KRT19 keratin 19, type I
MAOB monoamine oxidase B
MSRB2 methionine sulfoxide reductase B2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDZK1 PDZ domain containing 1
PON2 paraoxonase 2
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSPH phosphoserine phosphatase
PXMP2 peroxisomal membrane protein 2, 22kDa
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RHOBTB3 Rho-related BTB domain containing 3
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SLC16A6 solute carrier family 16, member 6
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPINK1 serine peptidase inhibitor, Kazal type 1
TAC1 tachykinin, precursor 1
TARBP1 TAR (HIV-1) RNA binding protein 1
TMEM255A transmembrane protein 255A
TSPAN3 tetraspanin 3
TSPAN8 tetraspanin 8
XYLT1 xylosyltransferase I
ZIC1 Zic family member 1
ZNF586 zinc finger protein 586