BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

267 genes differentially expressed following the BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AEBP1 AE binding protein 1
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ARC activity-regulated cytoskeleton-associated protein
ASCL1 achaete-scute family bHLH transcription factor 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BAG3 BCL2-associated athanogene 3
BGN biglycan
BMP6 bone morphogenetic protein 6
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CALCA calcitonin-related polypeptide alpha
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CECR1 cat eye syndrome chromosome region, candidate 1
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLEC5A C-type lectin domain family 5, member A
COL11A1 collagen, type XI, alpha 1
COL2A1 collagen, type II, alpha 1
COL8A2 collagen, type VIII, alpha 2
CORO1A coronin, actin binding protein, 1A
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSRP2 cysteine and glycine-rich protein 2
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDR2 discoidin domain receptor tyrosine kinase 2
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EIF1 eukaryotic translation initiation factor 1
FOXO3 forkhead box O3
G0S2 G0/G1 switch 2
GAS6 growth arrest-specific 6
GCLM glutamate-cysteine ligase, modifier subunit
GLS glutaminase
GPM6B glycoprotein M6B
H1F0 H1 histone family, member 0
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
IL32 interleukin 32
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
INSM1 insulinoma-associated 1
ITM2C integral membrane protein 2C
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLHL21 kelch-like family member 21
LDLR low density lipoprotein receptor
LRRC15 leucine rich repeat containing 15
LRRC49 leucine rich repeat containing 49
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2A1 mannosidase, alpha, class 2A, member 1
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEG3 maternally expressed 3 (non-protein coding)
MMP9 matrix metallopeptidase 9
MT1F metallothionein 1F
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
NACA nascent polypeptide-associated complex alpha subunit
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC1 Niemann-Pick disease, type C1
NPTX2 neuronal pentraxin II
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRCAM neuronal cell adhesion molecule
OSER1 oxidative stress responsive serine-rich 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCDH9 protocadherin 9
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PKD1P1 polycystic kidney disease 1 (autosomal dominant) pseudogene 1
PLIN2 perilipin 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PXDN peroxidasin
RABGGTB Rab geranylgeranyltransferase, beta subunit
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS1 regulator of G-protein signaling 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL10 ribosomal protein L10
RUNX3 runt-related transcription factor 3
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNX7 sorting nexin 7
SQSTM1 sequestosome 1
SST somatostatin
STAR steroidogenic acute regulatory protein
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
THBS2 thrombospondin 2
TMEM2 transmembrane protein 2
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ABHD10 abhydrolase domain containing 10
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADCY1 adenylate cyclase 1 (brain)
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AGTR1 angiotensin II receptor, type 1
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPH aspartate beta-hydroxylase
ATMIN ATM interactor
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CBR3 carbonyl reductase 3
CCDC92 coiled-coil domain containing 92
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CD47 CD47 molecule
CDC20 cell division cycle 20
CLIC3 chloride intracellular channel 3
COX11 COX11 cytochrome c oxidase copper chaperone
CST3 cystatin C
CTSH cathepsin H
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DAPK1 death-associated protein kinase 1
DCXR dicarbonyl/L-xylulose reductase
DEGS1 delta(4)-desaturase, sphingolipid 1
DES desmin
DLD dihydrolipoamide dehydrogenase
EMP3 epithelial membrane protein 3
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EXOSC4 exosome component 4
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FXYD3 FXYD domain containing ion transport regulator 3
GAS2L1 growth arrest-specific 2 like 1
GATA2 GATA binding protein 2
GHR growth hormone receptor
GLRX glutaredoxin (thioltransferase)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPER1 G protein-coupled estrogen receptor 1
GPRC5B G protein-coupled receptor, class C, group 5, member B
HLF hepatic leukemia factor
HOPX HOP homeobox
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICMT isoprenylcysteine carboxyl methyltransferase
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INTS5 integrator complex subunit 5
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KIF20A kinesin family member 20A
KLK2 kallikrein-related peptidase 2
KLK3 kallikrein-related peptidase 3
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LTF lactotransferrin
LYPLA1 lysophospholipase I
MAGED1 melanoma antigen family D1
MAOA monoamine oxidase A
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MITF microphthalmia-associated transcription factor
MMD monocyte to macrophage differentiation-associated
MRPL17 mitochondrial ribosomal protein L17
MRPL39 mitochondrial ribosomal protein L39
MRPS16 mitochondrial ribosomal protein S16
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NKX3-1 NK3 homeobox 1
NOTCH2 notch 2
NPY neuropeptide Y
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
OPN3 opsin 3
OXLD1 oxidoreductase-like domain containing 1
PCGF2 polycomb group ring finger 2
PCNA proliferating cell nuclear antigen
PDLIM5 PDZ and LIM domain 5
PEX11A peroxisomal biogenesis factor 11 alpha
PLS1 plastin 1
PODXL podocalyxin-like
PON2 paraoxonase 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCA protein kinase C, alpha
PSD3 pleckstrin and Sec7 domain containing 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RER1 retention in endoplasmic reticulum sorting receptor 1
RGS2 regulator of G-protein signaling 2
RRAGA Ras-related GTP binding A
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SDC2 syndecan 2
SESN1 sestrin 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLIRP SRA stem-loop interacting RNA binding protein
SNX10 sorting nexin 10
SPDEF SAM pointed domain containing ETS transcription factor
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
TMEM50B transmembrane protein 50B
TMPRSS2 transmembrane protease, serine 2
TMX1 thioredoxin-related transmembrane protein 1
TMX4 thioredoxin-related transmembrane protein 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM1 tropomyosin 1 (alpha)
TRAM1 translocation associated membrane protein 1
TRIB1 tribbles pseudokinase 1
TSC22D1 TSC22 domain family, member 1
TSNAX translin-associated factor X
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
ZNF185 zinc finger protein 185 (LIM domain)
ZNHIT3 zinc finger, HIT-type containing 3