BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

188 genes differentially expressed following the BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA10 annexin A10
BEX1 brain expressed, X-linked 1
CCND2 cyclin D2
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
COL15A1 collagen, type XV, alpha 1
CYB5R2 cytochrome b5 reductase 2
DMD dystrophin
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DST dystonin
ETV1 ets variant 1
FAM63A family with sequence similarity 63, member A
FBXO11 F-box protein 11
FGF2 fibroblast growth factor 2 (basic)
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FRY furry homolog (Drosophila)
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPM6B glycoprotein M6B
GPRASP1 G protein-coupled receptor associated sorting protein 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL1RN interleukin 1 receptor antagonist
IL6ST interleukin 6 signal transducer
KANK1 KN motif and ankyrin repeat domains 1
KRT6A keratin 6A, type II
LIPG lipase, endothelial
LY96 lymphocyte antigen 96
LYN LYN proto-oncogene, Src family tyrosine kinase
MARCKS myristoylated alanine-rich protein kinase C substrate
MEF2C myocyte enhancer factor 2C
METTL7A methyltransferase like 7A
NAMPT nicotinamide phosphoribosyltransferase
NAV2 neuron navigator 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCDH7 protocadherin 7
PEG3 paternally expressed 3
PGAP1 post-GPI attachment to proteins 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK2 polo-like kinase 2
POSTN periostin, osteoblast specific factor
PTHLH parathyroid hormone-like hormone
RHOBTB3 Rho-related BTB domain containing 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A8 S100 calcium binding protein A8
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
STC1 stanniocalcin 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TF transferrin
TGFA transforming growth factor, alpha
TRIM22 tripartite motif containing 22
VCAN versican
VLDLR very low density lipoprotein receptor
VNN1 vanin 1
ZIC3 Zic family member 3

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACACA acetyl-CoA carboxylase alpha
ACAT1 acetyl-CoA acetyltransferase 1
ACLY ATP citrate lyase
ACSL1 acyl-CoA synthetase long-chain family member 1
AGR2 anterior gradient 2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMD1 adenosylmethionine decarboxylase 1
ANXA11 annexin A11
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
BASP1 brain abundant, membrane attached signal protein 1
BGN biglycan
CAPNS1 calpain, small subunit 1
CAPZB capping protein (actin filament) muscle Z-line, beta
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CD320 CD320 molecule
CD47 CD47 molecule
CDC42 cell division cycle 42
CDK19 cyclin-dependent kinase 19
CHERP calcium homeostasis endoplasmic reticulum protein
CKB creatine kinase, brain
COL6A2 collagen, type VI, alpha 2
COLGALT1 collagen beta(1-O)galactosyltransferase 1
COMT catechol-O-methyltransferase
COPE coatomer protein complex, subunit epsilon
CP ceruloplasmin (ferroxidase)
DCXR dicarbonyl/L-xylulose reductase
DHCR24 24-dehydrocholesterol reductase
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DUSP1 dual specificity phosphatase 1
ESD esterase D
FADS2 fatty acid desaturase 2
FASN fatty acid synthase
FGFR3 fibroblast growth factor receptor 3
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GATA2 GATA binding protein 2
GDF15 growth differentiation factor 15
GLOD4 glyoxalase domain containing 4
GNAS GNAS complex locus
GOLM1 golgi membrane protein 1
GPI glucose-6-phosphate isomerase
GTF3A general transcription factor IIIA
GUSB glucuronidase, beta
H1F0 H1 histone family, member 0
H2AFY H2A histone family, member Y
HMG20B high mobility group 20B
HOXA10 homeobox A10
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KLK3 kallikrein-related peptidase 3
KRT18 keratin 18, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY6E lymphocyte antigen 6 complex, locus E
LYPLA1 lysophospholipase I
MAGED1 melanoma antigen family D1
MARCKSL1 MARCKS-like 1
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
MCOLN1 mucolipin 1
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MPST mercaptopyruvate sulfurtransferase
MSMB microseminoprotein, beta-
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NKX3-1 NK3 homeobox 1
ODC1 ornithine decarboxylase 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCNA proliferating cell nuclear antigen
PHGDH phosphoglycerate dehydrogenase
PKN1 protein kinase N1
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRDX6 peroxiredoxin 6
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTMS parathymosin
PTOV1 prostate tumor overexpressed 1
PYCR1 pyrroline-5-carboxylate reductase 1
RAE1 ribonucleic acid export 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBM42 RNA binding motif protein 42
REXO2 RNA exonuclease 2
RGS10 regulator of G-protein signaling 10
RPL36 ribosomal protein L36
RPN1 ribophorin I
RRBP1 ribosome binding protein 1
SFTPA2 surfactant protein A2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPDEF SAM pointed domain containing ETS transcription factor
ST7 suppression of tumorigenicity 7
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TAPBP TAP binding protein (tapasin)
TARP TCR gamma alternate reading frame protein
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TBCB tubulin folding cofactor B
TGM2 transglutaminase 2
TM9SF3 transmembrane 9 superfamily member 3
TRAPPC3 trafficking protein particle complex 3
TRIM28 tripartite motif containing 28
TSC22D1 TSC22 domain family, member 1
TSPAN4 tetraspanin 4
TST thiosulfate sulfurtransferase (rhodanese)
TYMS thymidylate synthetase
UBE2S ubiquitin-conjugating enzyme E2S
UBE3C ubiquitin protein ligase E3C
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZNF146 zinc finger protein 146