BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

283 genes differentially expressed following the BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ADCY2 adenylate cyclase 2 (brain)
ASPN asporin
ATF4 activating transcription factor 4
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BMP7 bone morphogenetic protein 7
CADM1 cell adhesion molecule 1
CALML5 calmodulin-like 5
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
COL11A1 collagen, type XI, alpha 1
CPA3 carboxypeptidase A3 (mast cell)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DSC2 desmocollin 2
DTNA dystrobrevin, alpha
EFS embryonal Fyn-associated substrate
EGFR epidermal growth factor receptor
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPRS glutamyl-prolyl-tRNA synthetase
FXYD6 FXYD domain containing ion transport regulator 6
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GAREM GRB2 associated, regulator of MAPK1
GREM1 gremlin 1, DAN family BMP antagonist
GTPBP2 GTP binding protein 2
HEPH hephaestin
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IRF9 interferon regulatory factor 9
KRT6B keratin 6B, type II
LRP12 low density lipoprotein receptor-related protein 12
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP3L microfibrillar-associated protein 3-like
MMP1 matrix metallopeptidase 1
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MXI1 MAX interactor 1, dimerization protein
NCOA3 nuclear receptor coactivator 3
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PHGDH phosphoglycerate dehydrogenase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SARS seryl-tRNA synthetase
SCRG1 stimulator of chondrogenesis 1
SERINC5 serine incorporator 5
SERTAD2 SERTA domain containing 2
SH3BGR SH3 domain binding glutamate-rich protein
SIDT2 SID1 transmembrane family, member 2
SIK3 SIK family kinase 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK1 serine peptidase inhibitor, Kazal type 1
SQSTM1 sequestosome 1
STAB1 stabilin 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
WNK1 WNK lysine deficient protein kinase 1
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ACSF2 acyl-CoA synthetase family member 2
ACSL5 acyl-CoA synthetase long-chain family member 5
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADIRF adipogenesis regulatory factor
AIM1 absent in melanoma 1
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5 arachidonate 5-lipoxygenase
AOX1 aldehyde oxidase 1
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMT1 acidic residue methyltransferase 1
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASRGL1 asparaginase like 1
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
AXL AXL receptor tyrosine kinase
BASP1 brain abundant, membrane attached signal protein 1
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C3 complement component 3
C7 complement component 7
CA12 carbonic anhydrase XII
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCDC109B coiled-coil domain containing 109B
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CCNG1 cyclin G1
CDA cytidine deaminase
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CFI complement factor I
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKS2 CDC28 protein kinase regulatory subunit 2
CNN3 calponin 3, acidic
COL1A2 collagen, type I, alpha 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRYZ crystallin, zeta (quinone reductase)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTSC cathepsin C
CTSH cathepsin H
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DCK deoxycytidine kinase
DDB2 damage-specific DNA binding protein 2, 48kDa
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
ECI2 enoyl-CoA delta isomerase 2
ECT2 epithelial cell transforming 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EHD1 EH-domain containing 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP3 epithelial membrane protein 3
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2R coagulation factor II (thrombin) receptor
FAM3C family with sequence similarity 3, member C
G0S2 G0/G1 switch 2
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTSE1 G-2 and S-phase expressed 1
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMK granzyme K (granzyme 3; tryptase II)
HLTF helicase-like transcription factor
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HOXA10 homeobox A10
HOXB7 homeobox B7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICMT isoprenylcysteine carboxyl methyltransferase
IFI16 interferon, gamma-inducible protein 16
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP6 insulin-like growth factor binding protein 6
IL33 interleukin 33
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT7 keratin 7, type II
LAMB1 laminin, beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPA lipase A, lysosomal acid, cholesterol esterase
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKSL1 MARCKS-like 1
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MKI67 marker of proliferation Ki-67
MMD monocyte to macrophage differentiation-associated
MREG melanoregulin
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYD88 myeloid differentiation primary response 88
MYOF myoferlin
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCAPG non-SMC condensin I complex, subunit G
NCAPG2 non-SMC condensin II complex, subunit G2
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NNMT nicotinamide N-methyltransferase
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
NUSAP1 nucleolar and spindle associated protein 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAIP1 poly(A) binding protein interacting protein 1
PBK PDZ binding kinase
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PRKCH protein kinase C, eta
PRSS23 protease, serine, 23
PSCA prostate stem cell antigen
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PTGES prostaglandin E synthase
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RACGAP1 Rac GTPase activating protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIPK4 receptor-interacting serine-threonine kinase 4
RRM2 ribonucleotide reductase M2
S100A13 S100 calcium binding protein A13
S100A4 S100 calcium binding protein A4
SEC23A Sec23 homolog A (S. cerevisiae)
SEPW1 selenoprotein W, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHCBP1 SHC SH2-domain binding protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMC4 structural maintenance of chromosomes 4
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SRSF2 serine/arginine-rich splicing factor 2
STMN1 stathmin 1
STOM stomatin
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TAGLN2 transgelin 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TMEM14A transmembrane protein 14A
TMEM243 transmembrane protein 243, mitochondrial
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TSPAN6 tetraspanin 6
TUBB tubulin, beta class I
TWF2 twinfilin actin binding protein 2
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE3C ubiquitin protein ligase E3C
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
USP22 ubiquitin specific peptidase 22
WFDC2 WAP four-disulfide core domain 2