BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

200 genes differentially expressed following the BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABHD4 abhydrolase domain containing 4
AKR1C1 aldo-keto reductase family 1, member C1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
AZU1 azurocidin 1
BGN biglycan
BMP7 bone morphogenetic protein 7
BTG3 BTG family, member 3
CBR3 carbonyl reductase 3
CCND2 cyclin D2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COMP cartilage oligomeric matrix protein
CTSL cathepsin L
DDIT4 DNA-damage-inducible transcript 4
DEFA4 defensin, alpha 4, corticostatin
DLX2 distal-less homeobox 2
ELANE elastase, neutrophil expressed
EPAS1 endothelial PAS domain protein 1
ETV5 ets variant 5
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOSL1 FOS-like antigen 1
FOXF2 forkhead box F2
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GCLM glutamate-cysteine ligase, modifier subunit
GPM6B glycoprotein M6B
GPX1 glutathione peroxidase 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
JAG1 jagged 1
KDM3A lysine (K)-specific demethylase 3A
KIF1A kinesin family member 1A
KRT6A keratin 6A, type II
LRP4 low density lipoprotein receptor-related protein 4
LYPD1 LY6/PLAUR domain containing 1
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MPO myeloperoxidase
NPTX2 neuronal pentraxin II
PDGFA platelet-derived growth factor alpha polypeptide
PIR pirin (iron-binding nuclear protein)
PLAU plasminogen activator, urokinase
POPDC3 popeye domain containing 3
PTN pleiotrophin
RGCC regulator of cell cycle
S100P S100 calcium binding protein P
SFN stratifin
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
TUBB2B tubulin, beta 2B class IIb
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPP1 uridine phosphorylase 1
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACLY ATP citrate lyase
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AGR2 anterior gradient 2
AKAP7 A kinase (PRKA) anchor protein 7
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA6 annexin A6
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMT1 acidic residue methyltransferase 1
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BAMBI BMP and activin membrane-bound inhibitor
BCHE butyrylcholinesterase
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD200 CD200 molecule
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CENPA centromere protein A
CHEK2 checkpoint kinase 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COX17 COX17 cytochrome c oxidase copper chaperone
CTSH cathepsin H
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
DAAM1 dishevelled associated activator of morphogenesis 1
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ELOVL6 ELOVL fatty acid elongase 6
ESR1 estrogen receptor 1
FAM13A family with sequence similarity 13, member A
FAM63A family with sequence similarity 63, member A
FBP1 fructose-1,6-bisphosphatase 1
FEN1 flap structure-specific endonuclease 1
FGB fibrinogen beta chain
FLNB filamin B, beta
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLRX glutaredoxin (thioltransferase)
GRB14 growth factor receptor-bound protein 14
GREB1 growth regulation by estrogen in breast cancer 1
GRWD1 glutamate-rich WD repeat containing 1
HLTF helicase-like transcription factor
HOXC6 homeobox C6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP4 insulin-like growth factor binding protein 4
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMNB1 lamin B1
LOC100505650 uncharacterized LOC100505650
LPCAT1 lysophosphatidylcholine acyltransferase 1
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKSL1 MARCKS-like 1
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MLPH melanophilin
MSH6 mutS homolog 6
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MUC1 mucin 1, cell surface associated
MYB v-myb avian myeloblastosis viral oncogene homolog
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PCNA proliferating cell nuclear antigen
PDZK1 PDZ domain containing 1
PLA2G16 phospholipase A2, group XVI
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK1 polo-like kinase 1
PLS1 plastin 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PRSS23 protease, serine, 23
RAB25 RAB25, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBM47 RNA binding motif protein 47
RBPMS RNA binding protein with multiple splicing
RHOB ras homolog family member B
RPL31 ribosomal protein L31
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A4 S100 calcium binding protein A4
SELENBP1 selenium binding protein 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNRPE small nuclear ribonucleoprotein polypeptide E
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
STMN1 stathmin 1
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TMEM106C transmembrane protein 106C
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TSPAN6 tetraspanin 6
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VRK1 vaccinia related kinase 1
WEE1 WEE1 G2 checkpoint kinase
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
ZWINT ZW10 interacting kinetochore protein