BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

174 genes differentially expressed following the BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEMIP cell migration inducing protein, hyaluronan binding
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
COL1A1 collagen, type I, alpha 1
CSRP1 cysteine and glycine-rich protein 1
CXCL13 chemokine (C-X-C motif) ligand 13
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EMX2 empty spiracles homeobox 2
FGFR2 fibroblast growth factor receptor 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FZD10 frizzled class receptor 10
GAGE3 G antigen 3
GAS6 growth arrest-specific 6
GBP1 guanylate binding protein 1, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IGFBP7 insulin-like growth factor binding protein 7
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM3A lysine (K)-specific demethylase 3A
KLHL21 kelch-like family member 21
LST1 leukocyte specific transcript 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MFAP5 microfibrillar associated protein 5
MMP9 matrix metallopeptidase 9
MXI1 MAX interactor 1, dimerization protein
MYO6 myosin VI
OLFML2A olfactomedin-like 2A
OSBPL1A oxysterol binding protein-like 1A
OSER1 oxidative stress responsive serine-rich 1
PLIN2 perilipin 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGS5 regulator of G-protein signaling 5
RTN1 reticulon 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SESN1 sestrin 1
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SRGN serglycin
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
THY1 Thy-1 cell surface antigen
TPPP3 tubulin polymerization-promoting protein family member 3
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
WFS1 Wolfram syndrome 1 (wolframin)
XIST X inactive specific transcript (non-protein coding)
ZNF292 zinc finger protein 292
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACBD3 acyl-CoA binding domain containing 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
AIM1 absent in melanoma 1
AKAP8 A kinase (PRKA) anchor protein 8
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGAP29 Rho GTPase activating protein 29
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
AURKA aurora kinase A
B3GNT1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BST2 bone marrow stromal cell antigen 2
C1ORF116 chromosome 1 open reading frame 116
CCNA2 cyclin A2
CCNF cyclin F
CENPA centromere protein A
CFH complement factor H
CHPT1 choline phosphotransferase 1
CRIP1 cysteine-rich protein 1 (intestinal)
CTSC cathepsin C
CYB5A cytochrome b5 type A (microsomal)
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP6 dual specificity phosphatase 6
EED embryonic ectoderm development
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FBXW2 F-box and WD repeat domain containing 2
G0S2 G0/G1 switch 2
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GRN granulin
HES1 hes family bHLH transcription factor 1
HOXC6 homeobox C6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
JADE1 jade family PHD finger 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KIAA0100 KIAA0100
KIF20A kinesin family member 20A
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MED1 mediator complex subunit 1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGP matrix Gla protein
MSH6 mutS homolog 6
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO5C myosin VC
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NPY neuropeptide Y
NUSAP1 nucleolar and spindle associated protein 1
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCTP phosphatidylcholine transfer protein
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLK1 polo-like kinase 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTTG1 pituitary tumor-transforming 1
PURA purine-rich element binding protein A
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
RRP1B ribosomal RNA processing 1B
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SOX4 SRY (sex determining region Y)-box 4
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMPO thymopoietin
TNC tenascin C
TPD52L1 tumor protein D52-like 1
TSPAN1 tetraspanin 1
WRB tryptophan rich basic protein
WWTR1 WW domain containing transcription regulator 1
ZBTB18 zinc finger and BTB domain containing 18