BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

213 genes differentially expressed following the BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKAP13 A kinase (PRKA) anchor protein 13
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAG3 BCL2-associated athanogene 3
BBX bobby sox homolog (Drosophila)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CERS6 ceramide synthase 6
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
COL6A2 collagen, type VI, alpha 2
CRABP1 cellular retinoic acid binding protein 1
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR3 early growth response 3
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
GAL galanin/GMAP prepropeptide
GDF15 growth differentiation factor 15
HAUS3 HAUS augmin-like complex, subunit 3
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGA1 high mobility group AT-hook 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1R2 interleukin 1 receptor, type II
INSIG1 insulin induced gene 1
ITM2A integral membrane protein 2A
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JUN jun proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5A lysine (K)-specific demethylase 5A
KDM7A lysine (K)-specific demethylase 7A
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
LARP6 La ribonucleoprotein domain family, member 6
LGALS4 lectin, galactoside-binding, soluble, 4
LGALS8 lectin, galactoside-binding, soluble, 8
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MCL1 myeloid cell leukemia 1
MDK midkine (neurite growth-promoting factor 2)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIA melanoma inhibitory activity
MLF1 myeloid leukemia factor 1
MMP1 matrix metallopeptidase 1
MT1M metallothionein 1M
MTMR11 myotubularin related protein 11
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRCAM neuronal cell adhesion molecule
NT5E 5'-nucleotidase, ecto (CD73)
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PHIP pleckstrin homology domain interacting protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
POPDC3 popeye domain containing 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTN pleiotrophin
RNASET2 ribonuclease T2
RNMT RNA (guanine-7-) methyltransferase
S100P S100 calcium binding protein P
SASH1 SAM and SH3 domain containing 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERTAD2 SERTA domain containing 2
SLC22A18 solute carrier family 22, member 18
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK1 serine peptidase inhibitor, Kazal type 1
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRA2A transformer 2 alpha homolog (Drosophila)
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TSPAN8 tetraspanin 8
TWIST1 twist family bHLH transcription factor 1
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
ZBTB10 zinc finger and BTB domain containing 10
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACACA acetyl-CoA carboxylase alpha
AIM1 absent in melanoma 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASPH aspartate beta-hydroxylase
AURKA aurora kinase A
B3GNT1
BEX1 brain expressed, X-linked 1
C8ORF4 chromosome 8 open reading frame 4
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CD24 CD24 molecule
CD58 CD58 molecule
CD9 CD9 molecule
CDC123 cell division cycle 123
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CNN1 calponin 1, basic, smooth muscle
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CTPS1 CTP synthase 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DUSP22 dual specificity phosphatase 22
EID1 EP300 interacting inhibitor of differentiation 1
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
FXYD2 FXYD domain containing ion transport regulator 2
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GJA1 gap junction protein, alpha 1, 43kDa
GSPT2 G1 to S phase transition 2
HMGB3 high mobility group box 3
HOXA10 homeobox A10
HOXA5 homeobox A5
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ILK integrin-linked kinase
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
KIF2C kinesin family member 2C
LBR lamin B receptor
MCM3 minichromosome maintenance complex component 3
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MRPL15 mitochondrial ribosomal protein L15
MRPL33 mitochondrial ribosomal protein L33
MRPL34 mitochondrial ribosomal protein L34
MSH6 mutS homolog 6
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NPY neuropeptide Y
NREP neuronal regeneration related protein
NT5DC2 5'-nucleotidase domain containing 2
NUSAP1 nucleolar and spindle associated protein 1
PALLD palladin, cytoskeletal associated protein
PBX3 pre-B-cell leukemia homeobox 3
PCGF2 polycomb group ring finger 2
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PGAM1 phosphoglycerate mutase 1 (brain)
PHB prohibitin
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PNN pinin, desmosome associated protein
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POSTN periostin, osteoblast specific factor
PROSC proline synthetase co-transcribed homolog (bacterial)
PRSS23 protease, serine, 23
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SELT selenoprotein T
SEPHS1 selenophosphate synthetase 1
SFN stratifin
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPTSSA serine palmitoyltransferase, small subunit A
SRSF3 serine/arginine-rich splicing factor 3
SULF1 sulfatase 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TIMP3 TIMP metallopeptidase inhibitor 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM4 tropomyosin 4
TSPAN12 tetraspanin 12
TUBB6 tubulin, beta 6 class V
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UMPS uridine monophosphate synthetase
VCAM1 vascular cell adhesion molecule 1
VCAN versican