BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

193 genes differentially expressed following the BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADM adrenomedullin
AKAP13 A kinase (PRKA) anchor protein 13
AMDHD2 amidohydrolase domain containing 2
AQP1 aquaporin 1 (Colton blood group)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARMCX3 armadillo repeat containing, X-linked 3
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
CADM1 cell adhesion molecule 1
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CLEC2B C-type lectin domain family 2, member B
COL9A2 collagen, type IX, alpha 2
COL9A3 collagen, type IX, alpha 3
CTTN cortactin
DDIT3 DNA-damage-inducible transcript 3
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EPAS1 endothelial PAS domain protein 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXD1 forkhead box D1
GABPB1 GA binding protein transcription factor, beta subunit 1
GNAS GNAS complex locus
H1F0 H1 histone family, member 0
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM3A lysine (K)-specific demethylase 3A
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
KTN1 kinectin 1 (kinesin receptor)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NR4A1 nuclear receptor subfamily 4, group A, member 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCSK5 proprotein convertase subtilisin/kexin type 5
PFKL phosphofructokinase, liver
PHIP pleckstrin homology domain interacting protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNKP polynucleotide kinase 3'-phosphatase
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RHOB ras homolog family member B
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SPARCL1 SPARC-like 1 (hevin)
ST18 suppression of tumorigenicity 18, zinc finger
TMSB15A thymosin beta 15a
TREM1 triggering receptor expressed on myeloid cells 1
TRIB1 tribbles pseudokinase 1
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA6 annexin A6
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BTBD1 BTB (POZ) domain containing 1
C12ORF29 chromosome 12 open reading frame 29
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD200 CD200 molecule
CDC123 cell division cycle 123
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CKB creatine kinase, brain
COX11 COX11 cytochrome c oxidase copper chaperone
CRIP1 cysteine-rich protein 1 (intestinal)
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DACH1 dachshund family transcription factor 1
DUSP4 dual specificity phosphatase 4
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FOXA2 forkhead box A2
FXYD2 FXYD domain containing ion transport regulator 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GDI2 GDP dissociation inhibitor 2
GJA1 gap junction protein, alpha 1, 43kDa
GPX2 glutathione peroxidase 2
GRB14 growth factor receptor-bound protein 14
HOPX HOP homeobox
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA14 heat shock 70kDa protein 14
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IL32 interleukin 32
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
JADE2 jade family PHD finger 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KRT7 keratin 7, type II
LGALS1 lectin, galactoside-binding, soluble, 1
MAP2K6 mitogen-activated protein kinase kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MB myoglobin
MRPL15 mitochondrial ribosomal protein L15
MSH6 mutS homolog 6
MYO5C myosin VC
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NBN nibrin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRP2 NLR family, pyrin domain containing 2
NOP16 NOP16 nucleolar protein
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PON2 paraoxonase 2
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPIF peptidylprolyl isomerase F
PWP1 PWP1 homolog (S. cerevisiae)
RAB4A RAB4A, member RAS oncogene family
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SEPHS1 selenophosphate synthetase 1
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A46 solute carrier family 25, member 46
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SUB1 SUB1 homolog (S. cerevisiae)
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMX1 thioredoxin-related transmembrane protein 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TPM1 tropomyosin 1 (alpha)
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TSPAN12 tetraspanin 12
TXNDC9 thioredoxin domain containing 9
UBE2N ubiquitin-conjugating enzyme E2N
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UMPS uridine monophosphate synthetase
UPK1B uroplakin 1B
VCAN versican
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB18 zinc finger and BTB domain containing 18
ZCCHC24 zinc finger, CCHC domain containing 24