BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

239 genes differentially expressed following the BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMDHD2 amidohydrolase domain containing 2
ASS1 argininosuccinate synthase 1
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
CRISP3 cysteine-rich secretory protein 3
CTSA cathepsin A
CTTN cortactin
CUTA cutA divalent cation tolerance homolog (E. coli)
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DFNA5 deafness, autosomal dominant 5
DSG3 desmoglein 3
DUSP6 dual specificity phosphatase 6
EDN3 endothelin 3
EPAS1 endothelial PAS domain protein 1
FOSL1 FOS-like antigen 1
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS6 growth arrest-specific 6
GBAP1 glucosidase, beta, acid pseudogene 1
GREM1 gremlin 1, DAN family BMP antagonist
GRN granulin
GSN gelsolin
GTPBP2 GTP binding protein 2
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HPCAL1 hippocalcin-like 1
IDO1 indoleamine 2,3-dioxygenase 1
IER5 immediate early response 5
INPP1 inositol polyphosphate-1-phosphatase
KRT14 keratin 14, type I
LAMP1 lysosomal-associated membrane protein 1
LCK LCK proto-oncogene, Src family tyrosine kinase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MMP3 matrix metallopeptidase 3
NAV2 neuron navigator 2
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEBL nebulette
NMRK1 nicotinamide riboside kinase 1
NPC1 Niemann-Pick disease, type C1
NUPR1 nuclear protein, transcriptional regulator, 1
PAM peptidylglycine alpha-amidating monooxygenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLCB4 phospholipase C, beta 4
PLD3 phospholipase D family, member 3
PPAP2B phosphatidic acid phosphatase type 2B
PRAF2 PRA1 domain family, member 2
PRUNE2 prune homolog 2 (Drosophila)
PTX3 pentraxin 3, long
RNF187 ring finger protein 187
RRAGD Ras-related GTP binding D
SEC14L1 SEC14-like 1 (S. cerevisiae)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
STAB1 stabilin 1
STC2 stanniocalcin 2
STXBP1 syntaxin binding protein 1
TFE3 transcription factor binding to IGHM enhancer 3
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WDTC1 WD and tetratricopeptide repeats 1
XYLT1 xylosyltransferase I
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain
ACAT2 acetyl-CoA acetyltransferase 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA3 annexin A3
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASRGL1 asparaginase like 1
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BCLAF1 BCL2-associated transcription factor 1
BICC1 BicC family RNA binding protein 1
BIRC5 baculoviral IAP repeat containing 5
BST2 bone marrow stromal cell antigen 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BZW1 basic leucine zipper and W2 domains 1
C1QTNF3 C1q and tumor necrosis factor related protein 3
C3 complement component 3
C7 complement component 7
C8ORF4 chromosome 8 open reading frame 4
CALD1 caldesmon 1
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND3 cyclin D3
CD24 CD24 molecule
CD58 CD58 molecule
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDC45 cell division cycle 45
CDCA4 cell division cycle associated 4
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CFH complement factor H
CFI complement factor I
CFLAR CASP8 and FADD-like apoptosis regulator
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKB creatine kinase, brain
CLU clusterin
CP ceruloplasmin (ferroxidase)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
CRYZ crystallin, zeta (quinone reductase)
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
CYCS cytochrome c, somatic
DAPK1 death-associated protein kinase 1
DCK deoxycytidine kinase
DCXR dicarbonyl/L-xylulose reductase
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EAPP E2F-associated phosphoprotein
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAM64A family with sequence similarity 64, member A
FBXO21 F-box protein 21
FEN1 flap structure-specific endonuclease 1
FLRT3 fibronectin leucine rich transmembrane protein 3
GAS1 growth arrest-specific 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GSTA4 glutathione S-transferase alpha 4
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HAT1 histone acetyltransferase 1
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGB3 high mobility group box 3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
IFI16 interferon, gamma-inducible protein 16
IGFBP4 insulin-like growth factor binding protein 4
IGSF3 immunoglobulin superfamily, member 3
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LAMB1 laminin, beta 1
LMNB1 lamin B1
LOC100505650 uncharacterized LOC100505650
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKSL1 MARCKS-like 1
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MMD monocyte to macrophage differentiation-associated
MRPL12 mitochondrial ribosomal protein L12
MSH6 mutS homolog 6
MYH10 myosin, heavy chain 10, non-muscle
MYRF myelin regulatory factor
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPG2 non-SMC condensin II complex, subunit G2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUSAP1 nucleolar and spindle associated protein 1
OAT ornithine aminotransferase
PBK PDZ binding kinase
PDE4B phosphodiesterase 4B, cAMP-specific
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGM1 phosphoglucomutase 1
PLK1 polo-like kinase 1
PLSCR4 phospholipid scramblase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PRSS23 protease, serine, 23
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBPMS RNA binding protein with multiple splicing
RFC3 replication factor C (activator 1) 3, 38kDa
RGS2 regulator of G-protein signaling 2
RNASE4 ribonuclease, RNase A family, 4
RPL39L ribosomal protein L39-like
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SELT selenoprotein T
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFPQ splicing factor proline/glutamine-rich
SIVA1 SIVA1, apoptosis-inducing factor
SPC25 SPC25, NDC80 kinetochore complex component
SPON1 spondin 1, extracellular matrix protein
SPTSSA serine palmitoyltransferase, small subunit A
SRSF2 serine/arginine-rich splicing factor 2
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TACC3 transforming, acidic coiled-coil containing protein 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TMEM14A transmembrane protein 14A
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TRA2B transformer 2 beta homolog (Drosophila)
TSPAN6 tetraspanin 6
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UPK1B uroplakin 1B
VRK1 vaccinia related kinase 1
WFDC2 WAP four-disulfide core domain 2