BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

238 genes differentially expressed following the BRD-A76490030_2-[(chloroacetyl)(3,4-dimethylphenyl)amino]-N-cyclohexyl-2-pyridin-3-ylacetamide_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AKAP13 A kinase (PRKA) anchor protein 13
ALDOC aldolase C, fructose-bisphosphate
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAG3 BCL2-associated athanogene 3
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CTSL cathepsin L
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DSG3 desmoglein 3
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EPB41L3 erythrocyte membrane protein band 4.1-like 3
F3 coagulation factor III (thromboplastin, tissue factor)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP1 guanylate binding protein 1, interferon-inducible
GPM6B glycoprotein M6B
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
ISLR immunoglobulin superfamily containing leucine-rich repeat
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM3A lysine (K)-specific demethylase 3A
KDM6B lysine (K)-specific demethylase 6B
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KTN1 kinectin 1 (kinesin receptor)
LDLR low density lipoprotein receptor
LY6D lymphocyte antigen 6 complex, locus D
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MAST4 microtubule associated serine/threonine kinase family member 4
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MINK1 misshapen-like kinase 1
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP3 matrix metallopeptidase 3
MSX1 msh homeobox 1
MT1F metallothionein 1F
MT1M metallothionein 1M
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2A olfactomedin-like 2A
PDE2A phosphodiesterase 2A, cGMP-stimulated
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PKP1 plakophilin 1
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS10 regulator of G-protein signaling 10
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF167 ring finger protein 167
RRAD Ras-related associated with diabetes
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SELE selectin E
SELENBP1 selenium binding protein 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
SQSTM1 sequestosome 1
SRRM2 serine/arginine repetitive matrix 2
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
THBD thrombomodulin
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TP63 tumor protein p63
TRIB1 tribbles pseudokinase 1
TSC22D1 TSC22 domain family, member 1
TUBB2A tubulin, beta 2A class IIa
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
WISP2 WNT1 inducible signaling pathway protein 2
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ACP6 acid phosphatase 6, lysophosphatidic
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALCAM activated leukocyte cell adhesion molecule
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMCX2 armadillo repeat containing, X-linked 2
AURKA aurora kinase A
B3GNT1
BMI1 BMI1 proto-oncogene, polycomb ring finger
CCNA2 cyclin A2
CCND2 cyclin D2
CCNF cyclin F
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
COL1A2 collagen, type I, alpha 2
COL5A2 collagen, type V, alpha 2
CPD carboxypeptidase D
CYTL1 cytokine-like 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAAF2 dynein, axonemal, assembly factor 2
DUOX2 dual oxidase 2
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFR3A EFR3 homolog A (S. cerevisiae)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERBB3 erb-b2 receptor tyrosine kinase 3
EXOSC4 exosome component 4
F2R coagulation factor II (thrombin) receptor
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FBXO9 F-box protein 9
FEN1 flap structure-specific endonuclease 1
GRB14 growth factor receptor-bound protein 14
GSPT2 G1 to S phase transition 2
HES1 hes family bHLH transcription factor 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HOPX HOP homeobox
HOXA10 homeobox A10
HOXA5 homeobox A5
IGFBP7 insulin-like growth factor binding protein 7
IL27RA interleukin 27 receptor, alpha
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INTS5 integrator complex subunit 5
IQGAP2 IQ motif containing GTPase activating protein 2
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
KLHL9 kelch-like family member 9
KRT7 keratin 7, type II
LGALS1 lectin, galactoside-binding, soluble, 1
MAGED1 melanoma antigen family D1
MGP matrix Gla protein
MLEC malectin
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NISCH nischarin
NPY neuropeptide Y
NRIP1 nuclear receptor interacting protein 1
OLFM4 olfactomedin 4
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEG10 paternally expressed 10
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLK1 polo-like kinase 1
POSTN periostin, osteoblast specific factor
PRPF4 pre-mRNA processing factor 4
PSPH phosphoserine phosphatase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM47 RNA binding motif protein 47
RGS2 regulator of G-protein signaling 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SEPHS1 selenophosphate synthetase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A46 solute carrier family 25, member 46
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SRSF6 serine/arginine-rich splicing factor 6
SUOX sulfite oxidase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TNIK TRAF2 and NCK interacting kinase
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UNC119B unc-119 homolog B (C. elegans)
VCAN versican
YME1L1 YME1-like 1 ATPase