BRD-A75817871_blebbistatin_NCIH2073_6.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-A75817871_blebbistatin_NCIH2073_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALOX5 arachidonate 5-lipoxygenase
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
BTG1 B-cell translocation gene 1, anti-proliferative
C2CD2 C2 calcium-dependent domain containing 2
CA12 carbonic anhydrase XII
CAST calpastatin
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHRDL1 chordin-like 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
CRYAB crystallin, alpha B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DAPK1 death-associated protein kinase 1
DLK1 delta-like 1 homolog (Drosophila)
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EZR ezrin
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
GALC galactosylceramidase
HAL histidine ammonia-lyase
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HP haptoglobin
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP4 insulin-like growth factor binding protein 4
IL1R2 interleukin 1 receptor, type II
IQGAP1 IQ motif containing GTPase activating protein 1
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KLF5 Kruppel-like factor 5 (intestinal)
KLHL21 kelch-like family member 21
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
MALL mal, T-cell differentiation protein-like
MAOB monoamine oxidase B
MTUS1 microtubule associated tumor suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NAV3 neuron navigator 3
NPY1R neuropeptide Y receptor Y1
NTS neurotensin
PDLIM4 PDZ and LIM domain 4
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLXNB2 plexin B2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RAP1GAP RAP1 GTPase activating protein
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SOX9 SRY (sex determining region Y)-box 9
STAT5B signal transducer and activator of transcription 5B
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFF3 trefoil factor 3 (intestinal)
TLR4 toll-like receptor 4
TMEM164 transmembrane protein 164
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TSPAN8 tetraspanin 8
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ANOS1 anosmin 1
ASPN asporin
ATF3 activating transcription factor 3
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BEX4 brain expressed, X-linked 4
CD52 CD52 molecule
CEMIP cell migration inducing protein, hyaluronan binding
COL15A1 collagen, type XV, alpha 1
CPE carboxypeptidase E
CSRP1 cysteine and glycine-rich protein 1
CXCL10 chemokine (C-X-C motif) ligand 10
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
ESRP1 epithelial splicing regulatory protein 1
FGF9 fibroblast growth factor 9
FILIP1L filamin A interacting protein 1-like
FOSL1 FOS-like antigen 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GNAS GNAS complex locus
GREM1 gremlin 1, DAN family BMP antagonist
GRIA2 glutamate receptor, ionotropic, AMPA 2
HEG1 heart development protein with EGF-like domains 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFRD2 interferon-related developmental regulator 2
INHBA inhibin, beta A
INSM1 insulinoma-associated 1
ITGB6 integrin, beta 6
JUN jun proto-oncogene
LAMB1 laminin, beta 1
MAP7 microtubule-associated protein 7
NID1 nidogen 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PCBP2 poly(rC) binding protein 2
PEA15 phosphoprotein enriched in astrocytes 15
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PTGIS prostaglandin I2 (prostacyclin) synthase
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SULF1 sulfatase 1
TAGLN2 transgelin 2
TCF4 transcription factor 4
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM255A transmembrane protein 255A
TMEM30B transmembrane protein 30B
TYRP1 tyrosinase-related protein 1
ZNF331 zinc finger protein 331