BRD-A75817871_blebbistatin_A375_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

154 genes differentially expressed following the BRD-A75817871_blebbistatin_A375_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AHR aryl hydrocarbon receptor
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BAMBI BMP and activin membrane-bound inhibitor
BEX4 brain expressed, X-linked 4
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH13 cadherin 13
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
COL4A5 collagen, type IV, alpha 5
CPA3 carboxypeptidase A3 (mast cell)
CXCL11 chemokine (C-X-C motif) ligand 11
DDB2 damage-specific DNA binding protein 2, 48kDa
DYNLT3 dynein, light chain, Tctex-type 3
EPAS1 endothelial PAS domain protein 1
FDXR ferredoxin reductase
FOXF1 forkhead box F1
GBP2 guanylate binding protein 2, interferon-inducible
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
GULP1 GULP, engulfment adaptor PTB domain containing 1
HES1 hes family bHLH transcription factor 1
IL1B interleukin 1, beta
JAG1 jagged 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMCH1 LIM and calponin homology domains 1
MANSC1 MANSC domain containing 1
MEST mesoderm specific transcript
MPZL2 myelin protein zero-like 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLAT plasminogen activator, tissue
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POSTN periostin, osteoblast specific factor
PTHLH parathyroid hormone-like hormone
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGS5 regulator of G-protein signaling 5
RHOBTB1 Rho-related BTB domain containing 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS27L ribosomal protein S27-like
SESN1 sestrin 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SULF1 sulfatase 1
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TMEM2 transmembrane protein 2
TMEM35 transmembrane protein 35
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM22 tripartite motif containing 22
VGLL4 vestigial-like family member 4
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
AK4 adenylate kinase 4
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
AURKB aurora kinase B
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCLAF1 BCL2-associated transcription factor 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CLTB clathrin, light chain B
CPVL carboxypeptidase, vitellogenic-like
DPYSL2 dihydropyrimidinase-like 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
ECI2 enoyl-CoA delta isomerase 2
EGFR epidermal growth factor receptor
EMP3 epithelial membrane protein 3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
EZR ezrin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM171A1 family with sequence similarity 171, member A1
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FKBP5 FK506 binding protein 5
FOLR1 folate receptor 1 (adult)
FSTL1 follistatin-like 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPATCH8 G patch domain containing 8
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HELLS helicase, lymphoid-specific
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KLF6 Kruppel-like factor 6
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MKI67 marker of proliferation Ki-67
MT1E metallothionein 1E
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NUP210 nucleoporin 210kDa
NUSAP1 nucleolar and spindle associated protein 1
PARP2 poly (ADP-ribose) polymerase 2
PDGFA platelet-derived growth factor alpha polypeptide
PFKP phosphofructokinase, platelet
PI3 peptidase inhibitor 3, skin-derived
PIP prolactin-induced protein
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
SET SET nuclear proto-oncogene
SHCBP1 SHC SH2-domain binding protein 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMC2 structural maintenance of chromosomes 2
SORD sorbitol dehydrogenase
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFF3 trefoil factor 3 (intestinal)
TMEM45A transmembrane protein 45A
TMEM97 transmembrane protein 97
TMPO thymopoietin
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRIM29 tripartite motif containing 29
TSPYL5 TSPY-like 5
TUBB2A tubulin, beta 2A class IIa
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UGCG UDP-glucose ceramide glucosyltransferase
WHSC1 Wolf-Hirschhorn syndrome candidate 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein