BRD-A75517195_thiazolopyrimidine_PC3_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-A75517195_thiazolopyrimidine_PC3_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
BTG1 B-cell translocation gene 1, anti-proliferative
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CTH cystathionine gamma-lyase
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
EGFR epidermal growth factor receptor
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPS8 epidermal growth factor receptor pathway substrate 8
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GTPBP2 GTP binding protein 2
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IARS isoleucyl-tRNA synthetase
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
INHBE inhibin, beta E
LARP6 La ribonucleoprotein domain family, member 6
MARS methionyl-tRNA synthetase
MAST4 microtubule associated serine/threonine kinase family member 4
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NIT1 nitrilase 1
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
PTEN phosphatase and tensin homolog
PYCR1 pyrroline-5-carboxylate reductase 1
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RND3 Rho family GTPase 3
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RSL24D1 ribosomal L24 domain containing 1
SARS seryl-tRNA synthetase
SCG5 secretogranin V
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TARS threonyl-tRNA synthetase
TCEA1 transcription elongation factor A (SII), 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIB3 tribbles pseudokinase 3
UPP1 uridine phosphorylase 1
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
BAG3 BCL2-associated athanogene 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CDC25A cell division cycle 25A
CKB creatine kinase, brain
DICER1 dicer 1, ribonuclease type III
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
GLIPR1 GLI pathogenesis-related 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPB8 heat shock 22kDa protein 8
IGFBP3 insulin-like growth factor binding protein 3
KRT19 keratin 19, type I
MARCKSL1 MARCKS-like 1
MCM4 minichromosome maintenance complex component 4
MYH11 myosin, heavy chain 11, smooth muscle
NRIP1 nuclear receptor interacting protein 1
OAT ornithine aminotransferase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SOX4 SRY (sex determining region Y)-box 4
SRSF6 serine/arginine-rich splicing factor 6
TGM2 transglutaminase 2