BRD-A75517195_thiazolopyrimidine_A549_24.0_h_40.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-A75517195_thiazolopyrimidine_A549_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AARS alanyl-tRNA synthetase
ANXA3 annexin A3
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CD69 CD69 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CXCL3 chemokine (C-X-C motif) ligand 3
DDIT3 DNA-damage-inducible transcript 3
EREG epiregulin
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FLNB filamin B, beta
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FXYD3 FXYD domain containing ion transport regulator 3
GADD45A growth arrest and DNA-damage-inducible, alpha
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRB10 growth factor receptor-bound protein 10
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IARS isoleucyl-tRNA synthetase
IER3 immediate early response 3
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
N4BP2L2 NEDD4 binding protein 2-like 2
PDGFA platelet-derived growth factor alpha polypeptide
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPARG peroxisome proliferator-activated receptor gamma
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RGS5 regulator of G-protein signaling 5
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TFF1 trefoil factor 1
TRIB3 tribbles pseudokinase 3
TRIP6 thyroid hormone receptor interactor 6
TSC22D3 TSC22 domain family, member 3
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AMIGO2 adhesion molecule with Ig-like domain 2
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
C3 complement component 3
CADM1 cell adhesion molecule 1
CCNB2 cyclin B2
CCND3 cyclin D3
CD46 CD46 molecule, complement regulatory protein
CDC25A cell division cycle 25A
CLU clusterin
COL4A5 collagen, type IV, alpha 5
CP ceruloplasmin (ferroxidase)
DHCR24 24-dehydrocholesterol reductase
DHFR dihydrofolate reductase
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DPYSL2 dihydropyrimidinase-like 2
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
ENO1 enolase 1, (alpha)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FEN1 flap structure-specific endonuclease 1
FN1 fibronectin 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HES1 hes family bHLH transcription factor 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ICMT isoprenylcysteine carboxyl methyltransferase
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP3 insulin-like growth factor binding protein 3
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KLHDC3 kelch domain containing 3
LMNB1 lamin B1
LYPD1 LY6/PLAUR domain containing 1
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM7 minichromosome maintenance complex component 7
MLEC malectin
MSH6 mutS homolog 6
MYLK myosin light chain kinase
NRIP1 nuclear receptor interacting protein 1
NUSAP1 nucleolar and spindle associated protein 1
OIP5 Opa interacting protein 5
PBX1 pre-B-cell leukemia homeobox 1
PEG10 paternally expressed 10
PGK1 phosphoglycerate kinase 1
PKM pyruvate kinase, muscle
PLK1 polo-like kinase 1
PON2 paraoxonase 2
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM14A transmembrane protein 14A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TRIB2 tribbles pseudokinase 2
TSPAN12 tetraspanin 12
TSPAN6 tetraspanin 6
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A