BRD-A75301702_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-A75301702_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CD44 CD44 molecule (Indian blood group)
CHN2 chimerin 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COMP cartilage oligomeric matrix protein
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EIF5 eukaryotic translation initiation factor 5
EPS8 epidermal growth factor receptor pathway substrate 8
FAM134B family with sequence similarity 134, member B
FKBP14 FK506 binding protein 14, 22 kDa
FPGS folylpolyglutamate synthase
GOLM1 golgi membrane protein 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
INSIG2 insulin induced gene 2
IVNS1ABP influenza virus NS1A binding protein
LMO3 LIM domain only 3 (rhombotin-like 2)
LTBP1 latent transforming growth factor beta binding protein 1
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOTCH2NL notch 2 N-terminal like
NPIPB3 nuclear pore complex interacting protein family, member B3
PDGFC platelet derived growth factor C
PDGFD platelet derived growth factor D
PDPN podoplanin
PRDX4 peroxiredoxin 4
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RGS1 regulator of G-protein signaling 1
RPL10 ribosomal protein L10
RSRP1 arginine/serine-rich protein 1
SCRG1 stimulator of chondrogenesis 1
SFRP4 secreted frizzled-related protein 4
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SOD2 superoxide dismutase 2, mitochondrial
SYBU syntabulin (syntaxin-interacting)
TNC tenascin C

decreased expression

Symbol Name
CHRDL1 chordin-like 1
CLEC2B C-type lectin domain family 2, member B
ELANE elastase, neutrophil expressed
FCN1 ficolin (collagen/fibrinogen domain containing) 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXC6 homeobox C6
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
ITGA6 integrin, alpha 6
JADE2 jade family PHD finger 2
KCTD12 potassium channel tetramerization domain containing 12
KRT13 keratin 13, type I
MGP matrix Gla protein
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RBP4 retinol binding protein 4, plasma
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SOX4 SRY (sex determining region Y)-box 4
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TF transferrin
TGM2 transglutaminase 2
TOR1A torsin family 1, member A (torsin A)
TRAC T cell receptor alpha constant
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
TUBB6 tubulin, beta 6 class V