BRD-A74983348_(1S)-1-hydroxy-1,10a,12a-trimethyl-8-oxo-1,2,3,4,4a,4b,5,6,8,9,10,10a,10b,11,12,12a-hexadecahydrochrysen-2-yl acetate HZ-8_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

71 genes differentially expressed following the BRD-A74983348_(1S)-1-hydroxy-1,10a,12a-trimethyl-8-oxo-1,2,3,4,4a,4b,5,6,8,9,10,10a,10b,11,12,12a-hexadecahydrochrysen-2-yl acetate HZ-8_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AHR aryl hydrocarbon receptor
AREG amphiregulin
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
CCNA1 cyclin A1
CD14 CD14 molecule
CD163 CD163 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRABP2 cellular retinoic acid binding protein 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYD dihydropyrimidine dehydrogenase
DPYSL3 dihydropyrimidinase-like 3
GAS1 growth arrest-specific 1
GNAS GNAS complex locus
HPSE heparanase
IGFBP1 insulin-like growth factor binding protein 1
IRS1 insulin receptor substrate 1
KCTD12 potassium channel tetramerization domain containing 12
KLF10 Kruppel-like factor 10
LGALS3 lectin, galactoside-binding, soluble, 3
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NT5DC2 5'-nucleotidase domain containing 2
PDLIM5 PDZ and LIM domain 5
PEG3 paternally expressed 3
PFN2 profilin 2
PROM1 prominin 1
PTX3 pentraxin 3, long
RGS16 regulator of G-protein signaling 16
S100A11 S100 calcium binding protein A11
SCYL3 SCY1-like 3 (S. cerevisiae)
SELL selectin L
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPON2 spondin 2, extracellular matrix protein
TSPAN5 tetraspanin 5
TSPYL5 TSPY-like 5
TXNIP thioredoxin interacting protein
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
BMP2 bone morphogenetic protein 2
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CCND2 cyclin D2
CD24 CD24 molecule
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
CLC Charcot-Leyden crystal galectin
CRLF1 cytokine receptor-like factor 1
DHCR24 24-dehydrocholesterol reductase
FGFR3 fibroblast growth factor receptor 3
FZD5 frizzled class receptor 5
GATA3 GATA binding protein 3
HBD hemoglobin, delta
IL32 interleukin 32
JAG1 jagged 1
KCNK3 potassium channel, two pore domain subfamily K, member 3
KIZ kizuna centrosomal protein
LMO3 LIM domain only 3 (rhombotin-like 2)
LRP4 low density lipoprotein receptor-related protein 4
MAST4 microtubule associated serine/threonine kinase family member 4
MYH11 myosin, heavy chain 11, smooth muscle
NOP56 NOP56 ribonucleoprotein
OLFM4 olfactomedin 4
PANK2 pantothenate kinase 2
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RET ret proto-oncogene
SLC35F2 solute carrier family 35, member F2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
TSPAN1 tetraspanin 1
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1