BRD-A74134989_Structure possibly contains amino acid derivative which is not supported in current version!_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-A74134989_Structure possibly contains amino acid derivative which is not supported in current version!_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMDHD2 amidohydrolase domain containing 2
APOD apolipoprotein D
ASPN asporin
ATF3 activating transcription factor 3
BANK1 B-cell scaffold protein with ankyrin repeats 1
CCDC109B coiled-coil domain containing 109B
CCL2 chemokine (C-C motif) ligand 2
CD40 CD40 molecule, TNF receptor superfamily member 5
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKLF chemokine-like factor
CLGN calmegin
COL15A1 collagen, type XV, alpha 1
COL1A2 collagen, type I, alpha 2
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL5A2 collagen, type V, alpha 2
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DUOX2 dual oxidase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FGFR2 fibroblast growth factor receptor 2
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FYB FYN binding protein
GDF15 growth differentiation factor 15
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GSDMB gasdermin B
HOXC6 homeobox C6
IFI16 interferon, gamma-inducible protein 16
IGFBP5 insulin-like growth factor binding protein 5
IL27RA interleukin 27 receptor, alpha
IL7R interleukin 7 receptor
KRT13 keratin 13, type I
LEF1 lymphoid enhancer-binding factor 1
LTB lymphotoxin beta (TNF superfamily, member 3)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAL mal, T-cell differentiation protein
MDK midkine (neurite growth-promoting factor 2)
MEIS2 Meis homeobox 2
MEOX1 mesenchyme homeobox 1
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NKX3-1 NK3 homeobox 1
NPTX2 neuronal pentraxin II
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PALLD palladin, cytoskeletal associated protein
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
SFRP1 secreted frizzled-related protein 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SRGN serglycin
THYN1 thymocyte nuclear protein 1
TIAM1 T-cell lymphoma invasion and metastasis 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AREG amphiregulin
CA1 carbonic anhydrase I
CA12 carbonic anhydrase XII
CEMIP cell migration inducing protein, hyaluronan binding
CLIC3 chloride intracellular channel 3
DACH1 dachshund family transcription factor 1
EREG epiregulin
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KRT23 keratin 23, type I
LASP1 LIM and SH3 protein 1
MACF1 microtubule-actin crosslinking factor 1
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MARCKS myristoylated alanine-rich protein kinase C substrate
MGLL monoglyceride lipase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NPIPB3 nuclear pore complex interacting protein family, member B3
OXTR oxytocin receptor
PLAGL1 pleiomorphic adenoma gene-like 1
RHOB ras homolog family member B
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SOSTDC1 sclerostin domain containing 1
THBS1 thrombospondin 1
TLR4 toll-like receptor 4